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http://hdl.handle.net/10553/47059
| Título: | Secondary metabolites from two species of tolpis and their biological activities | Autores/as: | Triana Mendez,Jorge Marrero, María Teresa Brouard, Ignacio León, Francisco Lopez Sanchez,Mariana Perez Galvan,Francisco Javier Rico Santos, Milagros López-Monzón, Aroa Estévez Rosas, Francisco |
Clasificación UNESCO: | 230690 Química de productos naturales orgánicos | Palabras clave: | Asteraceae Tolpis proustii Tolpis lagopoda Ursane-triterpenes Taraxastane-triterpenes |
Fecha de publicación: | 2012 | Proyectos: | Aislamiento y Sistesis de Productos Naturales Con Actividad Citostitica de Plantas de la Familia Asteraceae Endemicas de Canarias. | Publicación seriada: | Molecules | Resumen: | Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3beta-acetoxy-22alfa-hydroxyl-20(21)- taraxastene (1), 3beta,22alfa-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3beta,28-dihydroxy- 11alfa-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines. | URI: | http://hdl.handle.net/10553/47059 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules171112895 | Fuente: | Molecules [ISSN 1420-3049], v. 17 (11), p. 12895-12909 | Derechos: | by-nc-nd |
| Colección: | Artículos |
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