Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46579
Título: The role of mannose-binding lectin in pneumococcal infection
Autores/as: García-Laorden, M. Isabel
Rodríguez De Castro, Felipe 
Solé-Violán, Jordi
Payeras, Antoni
Briones, M. Luisa
Borderías, Luis
Aspa, Javier
Blanquer, José
Rajas, Olga
Marcos-Ramos, J. Alberto
Herrera-Ramos, Estefanía
García-Bello, Miguel A.
Noda, Judith
Ferrer, José M.
Rello, Jordi
Rodríguez-Gallego, Carlos 
Clasificación UNESCO: 32 Ciencias médicas
320508 Enfermedades pulmonares
Palabras clave: Community-Acquired Pneumonia
Human Sp-A
Streptococcus-Pneumoniae
Surfactant Proteins
Innate Immunity, et al.
Fecha de publicación: 2013
Publicación seriada: European Respiratory Journal 
Resumen: The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.We studied 348 patients with pneumococcal community-acquired pneumonia (P-CAP) and 2,110 controls. A meta-analysis of MBL2 genotypes in susceptibility to P-CAP and to invasive pneumococcal disease (IPD) was also performed. The extent of LD of MBL2 with SFTPA1, SFTPA2 and SFTPD was analysed.MBL2 genotypes did not associate with either P-CAP or bacteraemic P-CAP in the case-control study. The MBL-deficient O/O genotype was significantly associated with higher risk of IPD in a meta-analysis, whereas the other MBL-deficient genotype (XA/O) showed a trend towards a protective role. We showed the existence of LD between MBL2 and SP genes.The data do not support a role of MBL deficiency on susceptibility to P-CAP or to IPD. LD among MBL2 and SP genes must be considered in studies on the role of MBL in infectious diseases.
URI: http://hdl.handle.net/10553/46579
ISSN: 0903-1936
DOI: 10.1183/09031936.00174111
Fuente: European Respiratory Journal [ISSN 0903-1936],v. 41, p. 131-139
Colección:Artículos
Adobe PDF (245,07 kB)
Vista completa

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.