Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46579
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dc.contributor.authorGarcía-Laorden, M. Isabelen_US
dc.contributor.authorRodríguez De Castro, Felipeen_US
dc.contributor.authorSolé-Violán, Jordien_US
dc.contributor.authorPayeras, Antonien_US
dc.contributor.authorBriones, M. Luisaen_US
dc.contributor.authorBorderías, Luisen_US
dc.contributor.authorAspa, Javieren_US
dc.contributor.authorBlanquer, Joséen_US
dc.contributor.authorRajas, Olgaen_US
dc.contributor.authorMarcos-Ramos, J. Albertoen_US
dc.contributor.authorHerrera-Ramos, Estefaníaen_US
dc.contributor.authorGarcía-Bello, Miguel A.en_US
dc.contributor.authorNoda, Judithen_US
dc.contributor.authorFerrer, José M.en_US
dc.contributor.authorRello, Jordien_US
dc.contributor.authorRodríguez-Gallego, Carlosen_US
dc.date.accessioned2018-11-23T05:55:53Z-
dc.date.available2018-11-23T05:55:53Z-
dc.date.issued2013en_US
dc.identifier.issn0903-1936en_US
dc.identifier.urihttp://hdl.handle.net/10553/46579-
dc.description.abstractThe role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.We studied 348 patients with pneumococcal community-acquired pneumonia (P-CAP) and 2,110 controls. A meta-analysis of MBL2 genotypes in susceptibility to P-CAP and to invasive pneumococcal disease (IPD) was also performed. The extent of LD of MBL2 with SFTPA1, SFTPA2 and SFTPD was analysed.MBL2 genotypes did not associate with either P-CAP or bacteraemic P-CAP in the case-control study. The MBL-deficient O/O genotype was significantly associated with higher risk of IPD in a meta-analysis, whereas the other MBL-deficient genotype (XA/O) showed a trend towards a protective role. We showed the existence of LD between MBL2 and SP genes.The data do not support a role of MBL deficiency on susceptibility to P-CAP or to IPD. LD among MBL2 and SP genes must be considered in studies on the role of MBL in infectious diseases.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Respiratory Journalen_US
dc.sourceEuropean Respiratory Journal [ISSN 0903-1936],v. 41, p. 131-139en_US
dc.subject32 Ciencias médicasen_US
dc.subject320508 Enfermedades pulmonaresen_US
dc.subject.otherCommunity-Acquired Pneumoniaen_US
dc.subject.otherHuman Sp-Aen_US
dc.subject.otherStreptococcus-Pneumoniaeen_US
dc.subject.otherSurfactant Proteinsen_US
dc.subject.otherInnate Immunityen_US
dc.subject.otherCanary-Islandsen_US
dc.subject.otherSusceptibilityen_US
dc.subject.otherDiseaseen_US
dc.subject.otherGenotypeen_US
dc.subject.otherAllelesen_US
dc.titleThe role of mannose-binding lectin in pneumococcal infectionen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1183/09031936.00174111en_US
dc.identifier.scopus84872170532-
dc.identifier.isi000313384700022-
dc.contributor.authorscopusid6506073949-
dc.contributor.authorscopusid55942667000-
dc.contributor.authorscopusid24391710100-
dc.contributor.authorscopusid16033363200-
dc.contributor.authorscopusid7006010004-
dc.contributor.authorscopusid16168865800-
dc.contributor.authorscopusid6602555827-
dc.contributor.authorscopusid7004176630-
dc.contributor.authorscopusid6505890335-
dc.contributor.authorscopusid24390906800-
dc.contributor.authorscopusid36952964800-
dc.contributor.authorscopusid36099016000-
dc.contributor.authorscopusid22735032900-
dc.contributor.authorscopusid54400475800-
dc.contributor.authorscopusid7202496973-
dc.contributor.authorscopusid7102682070-
dc.contributor.authorscopusid6602114379-
dc.description.lastpage139en_US
dc.description.firstpage131en_US
dc.relation.volume41en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid8480501-
dc.contributor.daisngid464249-
dc.contributor.daisngid31934158-
dc.contributor.daisngid927291-
dc.contributor.daisngid1423003-
dc.contributor.daisngid857548-
dc.contributor.daisngid952601-
dc.contributor.daisngid323613-
dc.contributor.daisngid1134484-
dc.contributor.daisngid6436106-
dc.contributor.daisngid2130906-
dc.contributor.daisngid1700450-
dc.contributor.daisngid4259298-
dc.contributor.daisngid30375245-
dc.contributor.daisngid15178-
dc.contributor.daisngid603384-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Garcia-Laorden, MI-
dc.contributor.wosstandardWOS:de Castro, FR-
dc.contributor.wosstandardWOS:Sole-Violan, J-
dc.contributor.wosstandardWOS:Payeras, A-
dc.contributor.wosstandardWOS:Briones, ML-
dc.contributor.wosstandardWOS:Borderias, L-
dc.contributor.wosstandardWOS:Aspa, J-
dc.contributor.wosstandardWOS:Blanquer, J-
dc.contributor.wosstandardWOS:Rajas, O-
dc.contributor.wosstandardWOS:Marcos-Ramos, JA-
dc.contributor.wosstandardWOS:Herrera-Ramos, E-
dc.contributor.wosstandardWOS:Garcia-Bello, MA-
dc.contributor.wosstandardWOS:Noda, J-
dc.contributor.wosstandardWOS:Ferrer, JM-
dc.contributor.wosstandardWOS:Rello, J-
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C-
dc.date.coverdateEnero 2013en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,992
dc.description.jcr7,125
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Médicas y Quirúrgicas-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
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