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Title: The role of mannose-binding lectin in pneumococcal infection
Authors: García-Laorden, M. Isabel
Rodríguez De Castro, Felipe 
Solé-Violán, Jordi
Payeras, Antoni
Briones, M. Luisa
Borderías, Luis
Aspa, Javier
Blanquer, José
Rajas, Olga
Marcos-Ramos, J. Alberto
Herrera-Ramos, Estefanía
García-Bello, Miguel A.
Noda, Judith
Ferrer, José M.
Rello, Jordi
Rodríguez-Gallego, Carlos 
UNESCO Clasification: 32 Ciencias médicas
320508 Enfermedades pulmonares
Keywords: Community-Acquired Pneumonia
Human Sp-A
Surfactant Proteins
Innate Immunity, et al
Issue Date: 2013
Journal: European Respiratory Journal 
Abstract: The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.We studied 348 patients with pneumococcal community-acquired pneumonia (P-CAP) and 2,110 controls. A meta-analysis of MBL2 genotypes in susceptibility to P-CAP and to invasive pneumococcal disease (IPD) was also performed. The extent of LD of MBL2 with SFTPA1, SFTPA2 and SFTPD was analysed.MBL2 genotypes did not associate with either P-CAP or bacteraemic P-CAP in the case-control study. The MBL-deficient O/O genotype was significantly associated with higher risk of IPD in a meta-analysis, whereas the other MBL-deficient genotype (XA/O) showed a trend towards a protective role. We showed the existence of LD between MBL2 and SP genes.The data do not support a role of MBL deficiency on susceptibility to P-CAP or to IPD. LD among MBL2 and SP genes must be considered in studies on the role of MBL in infectious diseases.
ISSN: 0903-1936
DOI: 10.1183/09031936.00174111
Source: European Respiratory Journal [ISSN 0903-1936],v. 41, p. 131-139
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