Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/46579
Title: | The role of mannose-binding lectin in pneumococcal infection | Authors: | García-Laorden, M. Isabel Rodríguez De Castro, Felipe Solé-Violán, Jordi Payeras, Antoni Briones, M. Luisa Borderías, Luis Aspa, Javier Blanquer, José Rajas, Olga Marcos-Ramos, J. Alberto Herrera-Ramos, Estefanía García-Bello, Miguel A. Noda, Judith Ferrer, José M. Rello, Jordi Rodríguez-Gallego, Carlos |
UNESCO Clasification: | 32 Ciencias médicas 320508 Enfermedades pulmonares |
Keywords: | Community-Acquired Pneumonia Human Sp-A Streptococcus-Pneumoniae Surfactant Proteins Innate Immunity, et al |
Issue Date: | 2013 | Journal: | European Respiratory Journal | Abstract: | The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.We studied 348 patients with pneumococcal community-acquired pneumonia (P-CAP) and 2,110 controls. A meta-analysis of MBL2 genotypes in susceptibility to P-CAP and to invasive pneumococcal disease (IPD) was also performed. The extent of LD of MBL2 with SFTPA1, SFTPA2 and SFTPD was analysed.MBL2 genotypes did not associate with either P-CAP or bacteraemic P-CAP in the case-control study. The MBL-deficient O/O genotype was significantly associated with higher risk of IPD in a meta-analysis, whereas the other MBL-deficient genotype (XA/O) showed a trend towards a protective role. We showed the existence of LD between MBL2 and SP genes.The data do not support a role of MBL deficiency on susceptibility to P-CAP or to IPD. LD among MBL2 and SP genes must be considered in studies on the role of MBL in infectious diseases. | URI: | http://hdl.handle.net/10553/46579 | ISSN: | 0903-1936 | DOI: | 10.1183/09031936.00174111 | Source: | European Respiratory Journal [ISSN 0903-1936],v. 41, p. 131-139 |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
37
checked on Nov 10, 2024
WEB OF SCIENCETM
Citations
34
checked on Nov 10, 2024
Page view(s)
80
checked on Aug 17, 2024
Download(s)
87
checked on Aug 17, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.