Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/35342
Título: In vitro activity of 1H-phenalen-1-one derivatives against Acanthamoeba castellanii Neff and their mechanisms of cell death
Autores/as: López-Arencibia, Atteneri
Reyes-Batlle, María
Blanco Freijo, Mónica
McNaughton-Smith, Grant
Martín Rodríguez, Patricia 
Fernandez-Perez, Leandro 
Sifaoui, Ines
Wagner, Carolina
García-Méndez, Ana B.
Rizo Liendo, Aitor
Bethencourt-Estrella, Carlos J.
Abad-Grillo, Teresa
Piñero, José E.
Lorenzo-Morales, Jacob
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Gene Sequence Type
Antifungal Activity
Keratitis
Identification
Apoptosis, et al.
Fecha de publicación: 2017
Publicación seriada: Experimental parasitology 
Resumen: Acanthamoeba is an opportunistic pathogen which is the causal agent of a sight-threatening ulceration of the cornea known as Acanthamoeba keratitis (AK) and, more rarely, an infection of the central nervous system called "granulomatous amoebic encephalitis" (GAE). The symptoms of AK are non-specific, and so it can be misdiagnosed as a viral, bacterial, or fungal keratitis. Furthermore, current therapeutic measures against AK are arduous, and show limited efficacy against the cyst stage of Acanthamoeba. 1. H-Phenalen-1-one (PH) containing compounds have been isolated from plants and fungi, where they play a crucial role in the defense mechanism of plants. Natural as well as synthetic PHs exhibit a diverse range of biological activities against fungi, protozoan parasites or human cancer cells. New synthetic PHs have been tested in this study and they show a potential activity against this protozoa.
URI: http://hdl.handle.net/10553/35342
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2017.09.012
Fuente: Experimental Parasitology [ISSN 0014-4894], v. 183, p. 218-223
Colección:Artículos
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