Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/35342
Title: In vitro activity of 1H-phenalen-1-one derivatives against Acanthamoeba castellanii Neff and their mechanisms of cell death
Authors: López-Arencibia, Atteneri
Reyes-Batlle, María
Blanco Freijo, Mónica
McNaughton-Smith, Grant
Martín Rodríguez, Patricia 
Fernandez-Perez, Leandro 
Sifaoui, Ines
Wagner, Carolina
García-Méndez, Ana B.
Rizo Liendo, Aitor
Bethencourt-Estrella, Carlos J.
Abad-Grillo, Teresa
Piñero, José E.
Lorenzo-Morales, Jacob
UNESCO Clasification: 32 Ciencias médicas
Keywords: Gene Sequence Type
Antifungal Activity
Keratitis
Identification
Apoptosis
Genotype
T4
Pathogenicity
Phytoalexins
Resistance
Issue Date: 2017
Journal: Experimental parasitology 
Abstract: Acanthamoeba is an opportunistic pathogen which is the causal agent of a sight-threatening ulceration of the cornea known as Acanthamoeba keratitis (AK) and, more rarely, an infection of the central nervous system called "granulomatous amoebic encephalitis" (GAE). The symptoms of AK are non-specific, and so it can be misdiagnosed as a viral, bacterial, or fungal keratitis. Furthermore, current therapeutic measures against AK are arduous, and show limited efficacy against the cyst stage of Acanthamoeba. 1. H-Phenalen-1-one (PH) containing compounds have been isolated from plants and fungi, where they play a crucial role in the defense mechanism of plants. Natural as well as synthetic PHs exhibit a diverse range of biological activities against fungi, protozoan parasites or human cancer cells. New synthetic PHs have been tested in this study and they show a potential activity against this protozoa.
URI: http://hdl.handle.net/10553/35342
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2017.09.012
Source: Experimental Parasitology [ISSN 0014-4894], v. 183, p. 218-223
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

6
checked on Feb 28, 2021

WEB OF SCIENCETM
Citations

6
checked on Feb 28, 2021

Page view(s)

7
checked on Feb 27, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.