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Title: Anti-inflammatory activity of glycolipids isolated from cyanobacterium Nodularia harveyana
Authors: Tena Pérez, Víctor
Apaza Ticona, Luis
Cabanillas, Alfredo H.
Maderuelo Corral, Santiago
Rosero Valencia, Diego Fernando
Martel Quintana, Antera 
Ortega Domenech, Montserrat
Rumbero Sánchez, Ángel
UNESCO Clasification: 230690 Química de productos naturales orgánicos
Keywords: Anti-Inflammatory
Nodularia Harveyana, et al
Issue Date: 2020
Journal: Natural Product Research 
Abstract: Activity-guided fractionations from the freshwater cyanobacterium Nodularia harveyana led to the isolation of two monogalactosyldiacylglycerols (MGDG), two digalactosyldiacylglycerols (DGDG), two monoglucosyldiacylglycerols (MGlcDG) and 1-(O-hexose)-3,25-hexacosanediol (HG). Structures were elucidated by a combination of 1D and 2D NMR analysis, HRMS and GC-MS. The potential for inhibition against TNF-α and NF-κB production of these seven compounds was tested in THP-1 cells. All compounds showed activity, but compound 7 showed higher inhibitory activity of TNF-α and NF-κB, with IC50 of 4.88 ± 0.13 and 3.64 ± 0.45 μM, respectively.
ISSN: 1478-6419
DOI: 10.1080/14786419.2020.1837808
Source: Natural Product Research [ISSN 1478-6419]
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