Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/75367
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dc.contributor.authorTena Pérez, Víctoren_US
dc.contributor.authorApaza Ticona, Luisen_US
dc.contributor.authorCabanillas, Alfredo H.en_US
dc.contributor.authorMaderuelo Corral, Santiagoen_US
dc.contributor.authorRosero Valencia, Diego Fernandoen_US
dc.contributor.authorMartel Quintana, Anteraen_US
dc.contributor.authorOrtega Domenech, Montserraten_US
dc.contributor.authorRumbero Sánchez, Ángelen_US
dc.date.accessioned2020-11-11T09:21:14Z-
dc.date.available2020-11-11T09:21:14Z-
dc.date.issued2021en_US
dc.identifier.issn1478-6419en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/75367-
dc.description.abstractActivity-guided fractionations from the freshwater cyanobacterium Nodularia harveyana led to the isolation of two monogalactosyldiacylglycerols (MGDG), two digalactosyldiacylglycerols (DGDG), two monoglucosyldiacylglycerols (MGlcDG) and 1-(O-hexose)-3,25-hexacosanediol (HG). Structures were elucidated by a combination of 1D and 2D NMR analysis, HRMS and GC-MS. The potential for inhibition against TNF-α and NF-κB production of these seven compounds was tested in THP-1 cells. All compounds showed activity, but compound 7 showed higher inhibitory activity of TNF-α and NF-κB, with IC50 of 4.88 ± 0.13 and 3.64 ± 0.45 μM, respectively.en_US
dc.languageengen_US
dc.relation.ispartofNatural Product Researchen_US
dc.sourceNatural Product Research [ISSN 1478-6419], v. 35(24), p. 6204-6209en_US
dc.subject230690 Química de productos naturales orgánicosen_US
dc.subject.otherAnti-Inflammatoryen_US
dc.subject.otherCyanobacteriumen_US
dc.subject.otherGlycolipidsen_US
dc.subject.otherNf-Κben_US
dc.subject.otherNodularia Harveyanaen_US
dc.subject.otherTnf-Αen_US
dc.titleAnti-inflammatory activity of glycolipids isolated from cyanobacterium Nodularia harveyanaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/14786419.2020.1837808en_US
dc.identifier.scopus85094610118-
dc.contributor.authorscopusid56072150900-
dc.contributor.authorscopusid55142024800-
dc.contributor.authorscopusid57200917147-
dc.contributor.authorscopusid57200920009-
dc.contributor.authorscopusid57200916252-
dc.contributor.authorscopusid57197486214-
dc.contributor.authorscopusid57200917636-
dc.contributor.authorscopusid57200916894-
dc.identifier.eissn1478-6427-
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-BASen_US
dc.description.sjr0,446
dc.description.jcr2,488
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
dc.description.miaricds11,0
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IOCAG: Oceanografía Biológica y Algología Aplicada-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.orcid0000-0002-7450-0505-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.fullNameMartel Quintana,Antera De Jesús-
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