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http://hdl.handle.net/10553/75367
| Título: | Anti-inflammatory activity of glycolipids isolated from cyanobacterium Nodularia harveyana | Autores/as: | Tena Pérez, Víctor Apaza Ticona, Luis Cabanillas, Alfredo H. Maderuelo Corral, Santiago Rosero Valencia, Diego Fernando Martel Quintana, Antera Ortega Domenech, Montserrat Rumbero Sánchez, Ángel |
Clasificación UNESCO: | 230690 Química de productos naturales orgánicos | Palabras clave: | Anti-Inflammatory Cyanobacterium Glycolipids Nf-Κb Nodularia Harveyana, et al. |
Fecha de publicación: | 2021 | Publicación seriada: | Natural Product Research | Resumen: | Activity-guided fractionations from the freshwater cyanobacterium Nodularia harveyana led to the isolation of two monogalactosyldiacylglycerols (MGDG), two digalactosyldiacylglycerols (DGDG), two monoglucosyldiacylglycerols (MGlcDG) and 1-(O-hexose)-3,25-hexacosanediol (HG). Structures were elucidated by a combination of 1D and 2D NMR analysis, HRMS and GC-MS. The potential for inhibition against TNF-α and NF-κB production of these seven compounds was tested in THP-1 cells. All compounds showed activity, but compound 7 showed higher inhibitory activity of TNF-α and NF-κB, with IC50 of 4.88 ± 0.13 and 3.64 ± 0.45 μM, respectively. | URI: | http://hdl.handle.net/10553/75367 | ISSN: | 1478-6419 | DOI: | 10.1080/14786419.2020.1837808 | Fuente: | Natural Product Research [ISSN 1478-6419], v. 35(24), p. 6204-6209 |
| Colección: | Artículos |
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