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Title: New lanostanoids from the fungus Ganoderma concinna
Authors: González, Antonio G. 
León, Francisco
Rivera, Augusto
Padrón, Juan I.
González-Plata, Javier
Zuluaga, Juan C.
Quintana, J 
Estévez, Francisco 
Bermejo, Jaime
Keywords: Lucidum
Cytotoxicity, et al
Issue Date: 2002
Publisher: 0163-3864
Journal: Journal of Natural Products 
Abstract: Three new compounds, 5alpha-lanosta-7,9(11),24-triene-3,8-hydroxy-26-al (1), 5alpha-lanosta-7,9(11),24-triene-15alpha-26-dihydroxy-3-one (2), and 8alpha,9alpha-epoxy-4,4,14alpha-trimethyl-3,7,11,15,20-pentaoxo-5alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds I and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.
ISSN: 0163-3864
DOI: 10.1021/np010143e
Source: Journal of Natural Products[ISSN 0163-3864],v. 65, p. 417-421
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