|Title:||New lanostanoids from the fungus Ganoderma concinna||Authors:||González, Antonio G.
Padrón, Juan I.
Zuluaga, Juan C.
|UNESCO Clasification:||32 Ciencias médicas
230692 Síntesis y estructura de productos naturales
Cytotoxicity, et al
|Issue Date:||2002||Journal:||Journal of Natural Products||Abstract:||Three new compounds, 5alpha-lanosta-7,9(11),24-triene-3,8-hydroxy-26-al (1), 5alpha-lanosta-7,9(11),24-triene-15alpha-26-dihydroxy-3-one (2), and 8alpha,9alpha-epoxy-4,4,14alpha-trimethyl-3,7,11,15,20-pentaoxo-5alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds I and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.||URI:||http://hdl.handle.net/10553/50580||ISSN:||0163-3864||DOI:||10.1021/np010143e||Source:||Journal of Natural Products[ISSN 0163-3864],v. 65, p. 417-421|
|Appears in Collections:||Artículos|
checked on Nov 19, 2023
WEB OF SCIENCETM
checked on Jul 9, 2023
checked on Nov 25, 2023
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.