|Title:||New lanostanoids from the fungus Ganoderma concinna||Authors:||González, Antonio G.
Padrón, Juan I.
Zuluaga, Juan C.
Cytotoxicity, et al
|Issue Date:||2002||Publisher:||0163-3864||Journal:||Journal of Natural Products||Abstract:||Three new compounds, 5alpha-lanosta-7,9(11),24-triene-3,8-hydroxy-26-al (1), 5alpha-lanosta-7,9(11),24-triene-15alpha-26-dihydroxy-3-one (2), and 8alpha,9alpha-epoxy-4,4,14alpha-trimethyl-3,7,11,15,20-pentaoxo-5alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds I and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.||URI:||http://hdl.handle.net/10553/50580||ISSN:||0163-3864||DOI:||10.1021/np010143e||Source:||Journal of Natural Products[ISSN 0163-3864],v. 65, p. 417-421|
|Appears in Collections:||Artículos|
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.