Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50580
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dc.contributor.authorGonzález, Antonio G.
dc.contributor.authorLeón, Francisco
dc.contributor.authorRivera, Augusto
dc.contributor.authorPadrón, Juan I.
dc.contributor.authorGonzález-Plata, Javier
dc.contributor.authorZuluaga, Juan C.
dc.contributor.authorQuintana, J
dc.contributor.authorEstévez, Francisco
dc.contributor.authorBermejo, Jaime
dc.contributor.otherEstevez, Francisco
dc.contributor.otherGonzalez-Platas, Javier
dc.contributor.otherQuintana, Jose
dc.contributor.otherPadron, Juan
dc.contributor.otherLeon, Francisco
dc.date.accessioned2018-11-24T17:09:33Z-
dc.date.available2018-11-24T17:09:33Z-
dc.date.issued2002
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/10553/50580-
dc.description.abstractThree new compounds, 5alpha-lanosta-7,9(11),24-triene-3,8-hydroxy-26-al (1), 5alpha-lanosta-7,9(11),24-triene-15alpha-26-dihydroxy-3-one (2), and 8alpha,9alpha-epoxy-4,4,14alpha-trimethyl-3,7,11,15,20-pentaoxo-5alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds I and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.
dc.publisher0163-3864
dc.relation.ispartofJournal of Natural Products
dc.sourceJournal of Natural Products[ISSN 0163-3864],v. 65, p. 417-421
dc.subject.otherLucidum
dc.subject.otherTriterpenoids
dc.subject.otherApoptosis
dc.subject.otherPotentiation
dc.subject.otherCytotoxicity
dc.subject.otherInduction
dc.subject.otherSteroids
dc.subject.otherCells
dc.titleNew lanostanoids from the fungus Ganoderma concinna
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1021/np010143e
dc.identifier.scopus0036193514
dc.identifier.isi000174627400037
dcterms.isPartOfJournal Of Natural Products
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 65 (3), p. 417-421
dc.contributor.authorscopusid56387707800
dc.contributor.authorscopusid7005039451
dc.contributor.authorscopusid7102211501
dc.contributor.authorscopusid7003856519
dc.contributor.authorscopusid39461259500
dc.contributor.authorscopusid39462356200
dc.contributor.authorscopusid8681043500
dc.contributor.authorscopusid7003810011
dc.contributor.authorscopusid7101636723
dc.description.lastpage421
dc.description.firstpage417
dc.relation.volume65
dc.type2Artículoes
dc.identifier.wosWOS:000174627400037
dc.contributor.daisngid21923
dc.contributor.daisngid914093
dc.contributor.daisngid136703
dc.contributor.daisngid244051
dc.contributor.daisngid618078
dc.contributor.daisngid21044458
dc.contributor.daisngid31999595
dc.contributor.daisngid5161593
dc.contributor.daisngid128315
dc.contributor.daisngid384944
dc.contributor.daisngid5695465
dc.identifier.investigatorRIDK-5125-2014
dc.identifier.investigatorRIDI-1937-2015
dc.identifier.investigatorRIDK-5709-2014
dc.identifier.investigatorRIDI-7660-2014
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Gonzalez, AG
dc.contributor.wosstandardWOS:Leon, F
dc.contributor.wosstandardWOS:Rivera, A
dc.contributor.wosstandardWOS:Padron, JI
dc.contributor.wosstandardWOS:Gonzalez-Plata, J
dc.contributor.wosstandardWOS:Zuluaga, JC
dc.contributor.wosstandardWOS:Quintana, J
dc.contributor.wosstandardWOS:Estevez, F
dc.contributor.wosstandardWOS:Bermejo, J
dc.date.coverdateAbril 2002
dc.identifier.ulpgces
dc.description.jcr1,855
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptIOCAG: Química Marina-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-5637-8841-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGonzález González, Aridane-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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