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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50580
DC FieldValueLanguage
dc.contributor.authorGonzález, Antonio G.en_US
dc.contributor.authorLeón, Franciscoen_US
dc.contributor.authorRivera, Augustoen_US
dc.contributor.authorPadrón, Juan I.en_US
dc.contributor.authorGonzález-Plata, Javieren_US
dc.contributor.authorZuluaga, Juan C.en_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.contributor.authorBermejo, Jaimeen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherGonzalez-Platas, Javier-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherPadron, Juan-
dc.contributor.otherLeon, Francisco-
dc.date.accessioned2018-11-24T17:09:33Z-
dc.date.available2018-11-24T17:09:33Z-
dc.date.issued2002en_US
dc.identifier.issn0163-3864en_US
dc.identifier.urihttp://hdl.handle.net/10553/50580-
dc.description.abstractThree new compounds, 5alpha-lanosta-7,9(11),24-triene-3,8-hydroxy-26-al (1), 5alpha-lanosta-7,9(11),24-triene-15alpha-26-dihydroxy-3-one (2), and 8alpha,9alpha-epoxy-4,4,14alpha-trimethyl-3,7,11,15,20-pentaoxo-5alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds I and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.sourceJournal of Natural Products[ISSN 0163-3864],v. 65, p. 417-421en_US
dc.subject32 Ciencias médicasen_US
dc.subject230692 Síntesis y estructura de productos naturalesen_US
dc.subject.otherLucidumen_US
dc.subject.otherTriterpenoidsen_US
dc.subject.otherApoptosisen_US
dc.subject.otherPotentiationen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherInductionen_US
dc.subject.otherSteroidsen_US
dc.subject.otherCellsen_US
dc.titleNew lanostanoids from the fungus Ganoderma concinnaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/np010143een_US
dc.identifier.scopus0036193514-
dc.identifier.isi000174627400037-
dcterms.isPartOfJournal Of Natural Products-
dcterms.sourceJournal Of Natural Products[ISSN 0163-3864],v. 65 (3), p. 417-421-
dc.contributor.authorscopusid56387707800-
dc.contributor.authorscopusid7005039451-
dc.contributor.authorscopusid7102211501-
dc.contributor.authorscopusid7003856519-
dc.contributor.authorscopusid39461259500-
dc.contributor.authorscopusid39462356200-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7101636723-
dc.description.lastpage421en_US
dc.description.firstpage417en_US
dc.relation.volume65en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000174627400037-
dc.contributor.daisngid21923-
dc.contributor.daisngid914093-
dc.contributor.daisngid136703-
dc.contributor.daisngid244051-
dc.contributor.daisngid618078-
dc.contributor.daisngid21044458-
dc.contributor.daisngid31999595-
dc.contributor.daisngid5161593-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.contributor.daisngid5695465-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDI-1937-2015-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDI-7660-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages5en_US
dc.utils.revisionSíen_US
dc.contributor.wosstandardWOS:Gonzalez, AG-
dc.contributor.wosstandardWOS:Leon, F-
dc.contributor.wosstandardWOS:Rivera, A-
dc.contributor.wosstandardWOS:Padron, JI-
dc.contributor.wosstandardWOS:Gonzalez-Plata, J-
dc.contributor.wosstandardWOS:Zuluaga, JC-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.contributor.wosstandardWOS:Bermejo, J-
dc.date.coverdateAbril 2002en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,855-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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