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| Title: | New lanostanoids from the fungus Ganoderma concinna | Authors: | González, Antonio G. León, Francisco Rivera, Augusto Padrón, Juan I. González-Plata, Javier Zuluaga, Juan C. Quintana, J Estévez, Francisco Bermejo, Jaime |
UNESCO Clasification: | 32 Ciencias médicas 230692 Síntesis y estructura de productos naturales |
Keywords: | Lucidum Triterpenoids Apoptosis Potentiation Cytotoxicity, et al |
Issue Date: | 2002 | Journal: | Journal of Natural Products | Abstract: | Three new compounds, 5alpha-lanosta-7,9(11),24-triene-3,8-hydroxy-26-al (1), 5alpha-lanosta-7,9(11),24-triene-15alpha-26-dihydroxy-3-one (2), and 8alpha,9alpha-epoxy-4,4,14alpha-trimethyl-3,7,11,15,20-pentaoxo-5alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds I and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis. | URI: | https://accedacris.ulpgc.es/handle/10553/50580 | ISSN: | 0163-3864 | DOI: | 10.1021/np010143e | Source: | Journal of Natural Products[ISSN 0163-3864],v. 65, p. 417-421 |
| Appears in Collections: | Artículos |
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