Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/50560
Title: alpha-Bromoacrylamido N-Substituted Isatin Derivatives as Potent Inducers of Apoptosis in Human Myeloid Leukemia Cells
Authors: Romagnoli, Romeo
Baraldi, Pier Giovanni
Cruz-Lopez, Olga
Preti, Delia
Bermejo, Jaime
Estévez, Francisco 
Keywords: Poly(Adp-Ribose) Polymerase
Anticancer Drugs
Cancer Cells
Death
Caspases, et al
Issue Date: 2009
Publisher: 1860-7179
Project: Desarrollo de Nuevos, Mas Seguros y Mas Efectivos Compuestos Antileucemicos 
Journal: ChemMedChem 
Abstract: A novel series of α-bromoacryloyl N-substituted isatin analogues were found to inhibit the growth and viability of human myeloid leukemia HL-60 and U-937 cells as well as human lymphoid leukemia MOLT-3 cells. These compounds show antiproliferative activity which may be mediated by apoptosis caused by cytochrome c release and caspase activation in human leukemia cells. © 2009 Wiley-VCH Verlag GmbH& Co. KGaA.
URI: http://hdl.handle.net/10553/50560
ISSN: 1860-7179
DOI: 10.1002/cmdc.200900245
Source: Chemmedchem[ISSN 1860-7179],v. 4 (10), p. 1668-1676
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