Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/50560
| Campo DC | Valor | idioma |
|---|---|---|
| dc.contributor.author | Romagnoli, Romeo | en_US |
| dc.contributor.author | Baraldi, Pier Giovanni | en_US |
| dc.contributor.author | Cruz-Lopez, Olga | en_US |
| dc.contributor.author | Preti, Delia | en_US |
| dc.contributor.author | Bermejo, Jaime | en_US |
| dc.contributor.author | Estévez, Francisco | en_US |
| dc.contributor.other | Baraldi, Pier Giovanni | - |
| dc.contributor.other | Romagnoli, Romeo | - |
| dc.contributor.other | Estevez, Francisco | - |
| dc.contributor.other | preti, delia | - |
| dc.contributor.other | Cruz-Lopez, Olga | - |
| dc.date.accessioned | 2018-11-24T17:00:04Z | - |
| dc.date.available | 2018-11-24T17:00:04Z | - |
| dc.date.issued | 2009 | en_US |
| dc.identifier.issn | 1860-7179 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10553/50560 | - |
| dc.description.abstract | A novel series of α-bromoacryloyl N-substituted isatin analogues were found to inhibit the growth and viability of human myeloid leukemia HL-60 and U-937 cells as well as human lymphoid leukemia MOLT-3 cells. These compounds show antiproliferative activity which may be mediated by apoptosis caused by cytochrome c release and caspase activation in human leukemia cells. | en_US |
| dc.language | eng | en_US |
| dc.relation | Desarrollo de Nuevos, Mas Seguros y Mas Efectivos Compuestos Antileucemicos | en_US |
| dc.relation.ispartof | ChemMedChem | en_US |
| dc.source | Chemmedchem[ISSN 1860-7179],v. 4 (10), p. 1668-1676 | en_US |
| dc.subject | 32 Ciencias médicas | en_US |
| dc.subject | 320713 Oncología | en_US |
| dc.subject.other | Poly(Adp-Ribose) Polymerase | en_US |
| dc.subject.other | Anticancer Drugs | en_US |
| dc.subject.other | Cancer Cells | en_US |
| dc.subject.other | Death | en_US |
| dc.subject.other | Caspases | en_US |
| dc.subject.other | Agents | en_US |
| dc.subject.other | Cytotoxicity | en_US |
| dc.subject.other | Inhibition | en_US |
| dc.subject.other | Mechanisms | en_US |
| dc.subject.other | Discovery | en_US |
| dc.title | alpha-Bromoacrylamido N-Substituted Isatin Derivatives as Potent Inducers of Apoptosis in Human Myeloid Leukemia Cells | en_US |
| dc.type | info:eu-repo/semantics/Article | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1002/cmdc.200900245 | en_US |
| dc.identifier.scopus | 70349774426 | - |
| dc.identifier.isi | 000270767900012 | - |
| dcterms.isPartOf | Chemmedchem | - |
| dcterms.source | Chemmedchem[ISSN 1860-7179],v. 4 (10), p. 1668-1676 | - |
| dc.contributor.authorscopusid | 7101729609 | - |
| dc.contributor.authorscopusid | 7101681318 | - |
| dc.contributor.authorscopusid | 23093335000 | - |
| dc.contributor.authorscopusid | 6602771700 | - |
| dc.contributor.authorscopusid | 7101636723 | - |
| dc.contributor.authorscopusid | 7003810011 | - |
| dc.description.lastpage | 1676 | en_US |
| dc.identifier.issue | 10 | - |
| dc.description.firstpage | 1668 | en_US |
| dc.relation.volume | 4 | en_US |
| dc.investigacion | Ciencias de la Salud | en_US |
| dc.type2 | Artículo | en_US |
| dc.identifier.wos | WOS:000270767900012 | - |
| dc.contributor.daisngid | 32727 | - |
| dc.contributor.daisngid | 38403 | - |
| dc.contributor.daisngid | 826766 | - |
| dc.contributor.daisngid | 428197 | - |
| dc.contributor.daisngid | 5695465 | - |
| dc.contributor.daisngid | 384944 | - |
| dc.identifier.investigatorRID | B-7933-2017 | - |
| dc.identifier.investigatorRID | G-9887-2015 | - |
| dc.identifier.investigatorRID | K-5125-2014 | - |
| dc.identifier.investigatorRID | G-9916-2015 | - |
| dc.identifier.investigatorRID | F-3060-2017 | - |
| dc.description.numberofpages | 9 | en_US |
| dc.utils.revision | Sí | en_US |
| dc.contributor.wosstandard | WOS:Romagnoli, R | - |
| dc.contributor.wosstandard | WOS:Baraldi, PG | - |
| dc.contributor.wosstandard | WOS:Cruz-Lopez, O | - |
| dc.contributor.wosstandard | WOS:Preti, D | - |
| dc.contributor.wosstandard | WOS:Bermejo, J | - |
| dc.contributor.wosstandard | WOS:Estevez, F | - |
| dc.date.coverdate | Octubre 2009 | en_US |
| dc.identifier.ulpgc | Sí | en_US |
| dc.contributor.buulpgc | BU-MED | en_US |
| dc.description.jcr | 3,232 | - |
| dc.description.jcrq | Q1 | - |
| dc.description.scie | SCIE | - |
| item.fulltext | Sin texto completo | - |
| item.grantfulltext | none | - |
| crisitem.author.dept | GIR IUIBS: Bioquímica | - |
| crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
| crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
| crisitem.author.orcid | 0000-0002-9728-2774 | - |
| crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
| crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
| crisitem.project.principalinvestigator | Estévez Rosas, Francisco Jesús | - |
| Colección: | Artículos | |
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