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http://hdl.handle.net/10553/50560
| Title: | alpha-Bromoacrylamido N-Substituted Isatin Derivatives as Potent Inducers of Apoptosis in Human Myeloid Leukemia Cells | Authors: | Romagnoli, Romeo Baraldi, Pier Giovanni Cruz-Lopez, Olga Preti, Delia Bermejo, Jaime Estévez, Francisco |
UNESCO Clasification: | 32 Ciencias médicas 320713 Oncología |
Keywords: | Poly(Adp-Ribose) Polymerase Anticancer Drugs Cancer Cells Death Caspases, et al |
Issue Date: | 2009 | Project: | Desarrollo de Nuevos, Mas Seguros y Mas Efectivos Compuestos Antileucemicos | Journal: | ChemMedChem | Abstract: | A novel series of α-bromoacryloyl N-substituted isatin analogues were found to inhibit the growth and viability of human myeloid leukemia HL-60 and U-937 cells as well as human lymphoid leukemia MOLT-3 cells. These compounds show antiproliferative activity which may be mediated by apoptosis caused by cytochrome c release and caspase activation in human leukemia cells. | URI: | http://hdl.handle.net/10553/50560 | ISSN: | 1860-7179 | DOI: | 10.1002/cmdc.200900245 | Source: | Chemmedchem[ISSN 1860-7179],v. 4 (10), p. 1668-1676 |
| Appears in Collections: | Artículos |
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