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Title: Pulsed ultrasounds accelerate healing of rib fractures in an experimental animal model: An effective new thoracic therapy?
Authors: Santana Rodríguez, Norberto 
Clavo, Bernardino 
Fernández-Pérez, Leandro 
Rivero, José C.
Travieso, María M.
Fiuza Pérez, Mª Dolores 
Villar, Jesús
Garcia Castellano, Jose Manuel 
Hernández-Pérez, Octavio 
Déniz Cáceres, Antonio 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Low-Intensity Ultrasound
Bone Regeneration
Issue Date: 2011
Project: Estudio funcional y molecular de las proteínas SOCS en un modelo de resistencia hepática a insulina. 
Journal: Journal of Thoracic and Cardiovascular Surgery 
Abstract: Objectives: Rib fractures are a frequent traumatic injury associated with a relatively high morbidity. Currently, the treatment of rib fractures is symptomatic. Since it has been reported that pulsed ultrasounds accelerates repair of limb fractures, we hypothesized that the application of pulsed ultrasounds will modify the course of healing in an animal model of rib fracture.Methods: We studied 136 male Sprague-Dawley rats. Animals were randomly assigned to different groups of doses (none, 50, 100, and 250 mW/cm(2) of intensity for 3 minutes per day) and durations (2, 10, 20, and 28 days) of treatment with pulsed ultrasounds. In every subgroup, we analyzed radiologic and histologic changes in the bone callus. In addition, we examined changes in gene expression of relevant genes involved in wound repair in both control and treated animals.Results: Histologic and radiologic consolidation was significantly increased by pulsed ultrasound treatment when applied for more than 10 days. The application of 50 mW/cm(2) was the most effective dose. Only the 100 and 250 mW/cm(2) doses were able to significantly increase messenger RNA expression of insulin-like growth factor 1, suppressor of cytokine signaling-2 and -3, and vascular endothelial growth factor and decrease monocyte chemoattractant protein-1 and collagen type II-alpha 1.Conclusions: Our findings indicate that pulsed ultrasound accelerates the consolidation of rib fractures. This study is the first to show that pulsed ultrasound promotes the healing of rib fractures. From a translational point of view, this easy, cheap technique could serve as an effective new therapeutic modality in patients with rib fractures.
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2010.06.028
Source: Journal of Thoracic and Cardiovascular Surgery[ISSN 0022-5223],v. 141 (5), p. 1253-1258
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