Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47730
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dc.contributor.authorSantana Rodríguez, Norbertoen_US
dc.contributor.authorClavo, Bernardinoen_US
dc.contributor.authorFernández-Pérez, Leandroen_US
dc.contributor.authorRivero, José C.en_US
dc.contributor.authorTravieso, María M.en_US
dc.contributor.authorFiuza Pérez, Mª Doloresen_US
dc.contributor.authorVillar, Jesúsen_US
dc.contributor.authorGarcia Castellano, Jose Manuelen_US
dc.contributor.authorHernández-Pérez, Octavioen_US
dc.contributor.authorDéniz Cáceres, Antonioen_US
dc.date.accessioned2018-11-23T15:56:21Z-
dc.date.available2018-11-23T15:56:21Z-
dc.date.issued2011en_US
dc.identifier.issn0022-5223en_US
dc.identifier.urihttp://hdl.handle.net/10553/47730-
dc.description.abstractObjectives: Rib fractures are a frequent traumatic injury associated with a relatively high morbidity. Currently, the treatment of rib fractures is symptomatic. Since it has been reported that pulsed ultrasounds accelerates repair of limb fractures, we hypothesized that the application of pulsed ultrasounds will modify the course of healing in an animal model of rib fracture.Methods: We studied 136 male Sprague-Dawley rats. Animals were randomly assigned to different groups of doses (none, 50, 100, and 250 mW/cm(2) of intensity for 3 minutes per day) and durations (2, 10, 20, and 28 days) of treatment with pulsed ultrasounds. In every subgroup, we analyzed radiologic and histologic changes in the bone callus. In addition, we examined changes in gene expression of relevant genes involved in wound repair in both control and treated animals.Results: Histologic and radiologic consolidation was significantly increased by pulsed ultrasound treatment when applied for more than 10 days. The application of 50 mW/cm(2) was the most effective dose. Only the 100 and 250 mW/cm(2) doses were able to significantly increase messenger RNA expression of insulin-like growth factor 1, suppressor of cytokine signaling-2 and -3, and vascular endothelial growth factor and decrease monocyte chemoattractant protein-1 and collagen type II-alpha 1.Conclusions: Our findings indicate that pulsed ultrasound accelerates the consolidation of rib fractures. This study is the first to show that pulsed ultrasound promotes the healing of rib fractures. From a translational point of view, this easy, cheap technique could serve as an effective new therapeutic modality in patients with rib fractures.en_US
dc.languageengen_US
dc.relationEstudio funcional y molecular de las proteínas SOCS en un modelo de resistencia hepática a insulina.en_US
dc.relation.ispartofJournal of Thoracic and Cardiovascular Surgeryen_US
dc.sourceJournal of Thoracic and Cardiovascular Surgery[ISSN 0022-5223],v. 141 (5), p. 1253-1258en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherLow-Intensity Ultrasounden_US
dc.subject.otherBone Regenerationen_US
dc.subject.otherGrowth-Factorsen_US
dc.subject.otherRepairen_US
dc.subject.otherPainen_US
dc.titlePulsed ultrasounds accelerate healing of rib fractures in an experimental animal model: An effective new thoracic therapy?en_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jtcvs.2010.06.028en_US
dc.identifier.scopus79954594700-
dc.identifier.isi000289546100031-
dc.contributor.authorscopusid56072780900-
dc.contributor.authorscopusid57190093030-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid7006478796-
dc.contributor.authorscopusid57212497992-
dc.contributor.authorscopusid57190760568-
dc.contributor.authorscopusid56698082300-
dc.contributor.authorscopusid55236061500-
dc.contributor.authorscopusid57192669803-
dc.contributor.authorscopusid6602732739-
dc.contributor.authorscopusid41861466800-
dc.contributor.authorscopusid41861243300-
dc.description.lastpage1258en_US
dc.description.firstpage1253en_US
dc.relation.volume141en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1685892-
dc.contributor.daisngid777033-
dc.contributor.daisngid795544-
dc.contributor.daisngid1995970-
dc.contributor.daisngid9976968-
dc.contributor.daisngid1466032-
dc.contributor.daisngid27320-
dc.contributor.daisngid2034496-
dc.contributor.daisngid3233444-
dc.contributor.daisngid12885802-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Santana-Rodriguez, N-
dc.contributor.wosstandardWOS:Clavo, B-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Rivero, JC-
dc.contributor.wosstandardWOS:Travieso, MM-
dc.contributor.wosstandardWOS:Fiuza, MD-
dc.contributor.wosstandardWOS:Villar, J-
dc.contributor.wosstandardWOS:Garcia-Castellano, JM-
dc.contributor.wosstandardWOS:Hernandez-Perez, O-
dc.contributor.wosstandardWOS:Deniz, A-
dc.date.coverdateMayo 2011en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,041-
dc.description.jcr3,406-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-2522-1064-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSantana Rodríguez, Norberto-
crisitem.author.fullNameClavo Varas, Bernardino-
crisitem.author.fullNameFernández Pérez, Leandro Fco-
crisitem.author.fullNameFiuza Pérez, Mª Dolores-
crisitem.author.fullNameGarcia Castellano, Jose Manuel-
crisitem.author.fullNameFernández Pérez, Leandro Fco-
crisitem.author.fullNameDéniz Cáceres, Antonio-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Fco-
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