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Title: Three combinations of clonidine in association with tiletamine-zolazepam for anaesthesia induction in rats: evaluation of reflexes and pain sensibility
Authors: Spinella, Giuseppe
Vilar Guereño, José Manuel 
Anastasi, C.
Santana Del Pino, Ángelo 
Prati, Ubaldo
Roveda, Laura
Ricciardi, Giulia
Britti, Domenico
UNESCO Clasification: 320990 Farmacología experimental
310908 Farmacología
321303 Anestesiología
Keywords: Anaesthesia induction
Reflex test
Winstar rats
Issue Date: 2012
Publisher: 0375-8427
Journal: Veterinární Medicína 
Abstract: The aim of this study was to assess the combination of tiletamine-zolazepam (Zoletil 20 (R)) with three different doses of clonidine for general anaesthesia induction in rats submitted to vascular microsurgery. The evaluation of anaesthetic and analgesic effects was performed in 30 Wistar rats randomly divided into three groups and induced with Zoletil 20 [90 mg/kg Intraperitoneal (IP)] associated with three different doses of clonidine (60-90-120 mu g/kg IP). Four clinical parameters were evaluated after induction: loss of righting reflex, voluntary movement, the pedal withdrawal response, and pain sensitivity tested by pinching the tail. The combination of Zoletil with 90 and 120 mu g/kg of clonidine provided a surgical anaesthesia; however, 90 mu g/kg of clonidine provided the most rapid anaesthesia induction, as confirmed by data obtained by clinical evaluation of the loss of the pedal withdrawal response and the absence of the tail pinch response. The increase in dose of clonidine did not lead to a more rapid action of the alpha 2 agonist, probably due to achievement of a dose-dependent plateau.
ISSN: 0375-8427
DOI: 10.17221/6365-VETMED
Source: Veterinarni Medicina [ISSN 0375-8427], v. 57 (10), p. 536-542
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