Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47400
Title: Three combinations of clonidine in association with tiletamine-zolazepam for anaesthesia induction in rats: evaluation of reflexes and pain sensibility
Authors: Spinella, Giuseppe
Vilar, J. M. 
Anastasi, C.
Santana, A.
Prati, U.
Roveda, L.
Ricciardi, G.
Britti, D.
UNESCO Clasification: 120903 Análisis de datos
240401 Bioestadística
Keywords: Ketamine-Xylazine
Issue Date: 2012
Publisher: 0375-8427
Journal: Veterinární Medicína 
Abstract: The aim of this study was to assess the combination of tiletamine-zolazepam (Zoletil 20 (R)) with three different doses of clonidine for general anaesthesia induction in rats submitted to vascular microsurgery. The evaluation of anaesthetic and analgesic effects was performed in 30 Wistar rats randomly divided into three groups and induced with Zoletil 20 [90 mg/kg Intraperitoneal (IP)] associated with three different doses of clonidine (60-90-120 mu g/kg IP). Four clinical parameters were evaluated after induction: loss of righting reflex, voluntary movement, the pedal withdrawal response, and pain sensitivity tested by pinching the tail. The combination of Zoletil with 90 and 120 mu g/kg of clonidine provided a surgical anaesthesia; however, 90 mu g/kg of clonidine provided the most rapid anaesthesia induction, as confirmed by data obtained by clinical evaluation of the loss of the pedal withdrawal response and the absence of the tail pinch response. The increase in dose of clonidine did not lead to a more rapid action of the alpha 2 agonist, probably due to achievement of a dose-dependent plateau.
URI: http://hdl.handle.net/10553/47400
ISSN: 0375-8427
DOI: 10.17221/6365-VETMED
Source: Veterinarni Medicina [ISSN 0375-8427], v. 57, p. 536-542
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

1
checked on Feb 28, 2021

WEB OF SCIENCETM
Citations

1
checked on Jan 24, 2021

Page view(s)

28
checked on Mar 1, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.