Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/47400
Título: Three combinations of clonidine in association with tiletamine-zolazepam for anaesthesia induction in rats: evaluation of reflexes and pain sensibility
Autores/as: Spinella, Giuseppe
Vilar Guereño, José Manuel 
Anastasi, C.
Santana Del Pino, Ángelo 
Prati, Ubaldo
Roveda, Laura
Ricciardi, Giulia
Britti, Domenico
Clasificación UNESCO: 320990 Farmacología experimental
310908 Farmacología
321303 Anestesiología
Palabras clave: Anaesthesia induction
Clonidine
Reflex test
Tiletamine-Zolazepam
Winstar rats
Fecha de publicación: 2012
Editor/a: 0375-8427
Publicación seriada: Veterinární Medicína 
Resumen: The aim of this study was to assess the combination of tiletamine-zolazepam (Zoletil 20 (R)) with three different doses of clonidine for general anaesthesia induction in rats submitted to vascular microsurgery. The evaluation of anaesthetic and analgesic effects was performed in 30 Wistar rats randomly divided into three groups and induced with Zoletil 20 [90 mg/kg Intraperitoneal (IP)] associated with three different doses of clonidine (60-90-120 mu g/kg IP). Four clinical parameters were evaluated after induction: loss of righting reflex, voluntary movement, the pedal withdrawal response, and pain sensitivity tested by pinching the tail. The combination of Zoletil with 90 and 120 mu g/kg of clonidine provided a surgical anaesthesia; however, 90 mu g/kg of clonidine provided the most rapid anaesthesia induction, as confirmed by data obtained by clinical evaluation of the loss of the pedal withdrawal response and the absence of the tail pinch response. The increase in dose of clonidine did not lead to a more rapid action of the alpha 2 agonist, probably due to achievement of a dose-dependent plateau.
URI: http://hdl.handle.net/10553/47400
ISSN: 0375-8427
DOI: 10.17221/6365-VETMED
Fuente: Veterinarni Medicina [ISSN 0375-8427], v. 57 (10), p. 536-542
Colección:Artículos
miniatura
Adobe PDF (180,2 kB)
Vista completa

Citas SCOPUSTM   

1
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

1
actualizado el 15-mar-2021

Visitas

95
actualizado el 13-ene-2024

Descargas

55
actualizado el 13-ene-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.