Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47400
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dc.contributor.authorSpinella, Giuseppeen_US
dc.contributor.authorVilar Guereño, José Manuelen_US
dc.contributor.authorAnastasi, C.en_US
dc.contributor.authorSantana Del Pino, Ángeloen_US
dc.contributor.authorPrati, Ubaldoen_US
dc.contributor.authorRoveda, Lauraen_US
dc.contributor.authorRicciardi, Giuliaen_US
dc.contributor.authorBritti, Domenicoen_US
dc.date.accessioned2018-11-23T13:15:58Z-
dc.date.available2018-11-23T13:15:58Z-
dc.date.issued2012en_US
dc.identifier.issn0375-8427en_US
dc.identifier.urihttp://hdl.handle.net/10553/47400-
dc.description.abstractThe aim of this study was to assess the combination of tiletamine-zolazepam (Zoletil 20 (R)) with three different doses of clonidine for general anaesthesia induction in rats submitted to vascular microsurgery. The evaluation of anaesthetic and analgesic effects was performed in 30 Wistar rats randomly divided into three groups and induced with Zoletil 20 [90 mg/kg Intraperitoneal (IP)] associated with three different doses of clonidine (60-90-120 mu g/kg IP). Four clinical parameters were evaluated after induction: loss of righting reflex, voluntary movement, the pedal withdrawal response, and pain sensitivity tested by pinching the tail. The combination of Zoletil with 90 and 120 mu g/kg of clonidine provided a surgical anaesthesia; however, 90 mu g/kg of clonidine provided the most rapid anaesthesia induction, as confirmed by data obtained by clinical evaluation of the loss of the pedal withdrawal response and the absence of the tail pinch response. The increase in dose of clonidine did not lead to a more rapid action of the alpha 2 agonist, probably due to achievement of a dose-dependent plateau.en_US
dc.languageengen_US
dc.publisher0375-8427-
dc.relation.ispartofVeterinární Medicínaen_US
dc.sourceVeterinarni Medicina [ISSN 0375-8427], v. 57 (10), p. 536-542en_US
dc.subject320990 Farmacología experimentalen_US
dc.subject310908 Farmacologíaen_US
dc.subject321303 Anestesiologíaen_US
dc.subject.otherAnaesthesia inductionen_US
dc.subject.otherClonidineen_US
dc.subject.otherReflex testen_US
dc.subject.otherTiletamine-Zolazepamen_US
dc.subject.otherWinstar ratsen_US
dc.titleThree combinations of clonidine in association with tiletamine-zolazepam for anaesthesia induction in rats: evaluation of reflexes and pain sensibilityen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.17221/6365-VETMEDen_US
dc.identifier.scopus84869443218-
dc.identifier.isi000311988200003-
dc.contributor.authorscopusid6602842395-
dc.contributor.authorscopusid7005533720-
dc.contributor.authorscopusid55488589900-
dc.contributor.authorscopusid56554207500-
dc.contributor.authorscopusid6603828457-
dc.contributor.authorscopusid6601988042-
dc.contributor.authorscopusid55488546700-
dc.contributor.authorscopusid6701857657-
dc.description.lastpage542en_US
dc.description.firstpage536en_US
dc.relation.volume57en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1106016-
dc.contributor.daisngid913655-
dc.contributor.daisngid4531217-
dc.contributor.daisngid4213964-
dc.contributor.daisngid986025-
dc.contributor.daisngid30554237-
dc.contributor.daisngid34949918-
dc.contributor.daisngid308782-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Spinella, G-
dc.contributor.wosstandardWOS:Vilar, JM-
dc.contributor.wosstandardWOS:Anastasi, C-
dc.contributor.wosstandardWOS:Santana, A-
dc.contributor.wosstandardWOS:Prati, U-
dc.contributor.wosstandardWOS:Roveda, L-
dc.contributor.wosstandardWOS:Ricciardi, G-
dc.contributor.wosstandardWOS:Britti, D-
dc.date.coverdateEnero 2012en_US
dc.identifier.ulpgcen_US
dc.description.sjr0,383
dc.description.jcr0,679
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR Medicina Veterinaria e Investigación Terapeútica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR Estadística-
crisitem.author.deptDepartamento de Matemáticas-
crisitem.author.orcid0000-0002-2060-2274-
crisitem.author.orcid0000-0002-6513-4814-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgDepartamento de Matemáticas-
crisitem.author.fullNameVilar Guereño, José Manuel-
crisitem.author.fullNameSantana Del Pino, Ángelo-
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