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Title: Microsatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer
Authors: Bilbao-Sieyro, Cristina 
Ramírez-Moreno, Raquel 
Rodríguez-González, Germán
Falcón, Orlando
León, Laureano
Torres, Santiago
Fernández, Leandro 
Alonso, Sergio
Díaz-Chico, Nicolás
Perucho, Manuel
Diaz-Chico, Juan Carlos 
UNESCO Clasification: 32 Ciencias médicas
320101 Oncología
Keywords: Adenomatous-Polyposis-Coli
Dna Mismatch Repair
Promoter Hypermethylation
Carcinoma, et al
Issue Date: 2014
Journal: Oncotarget 
Abstract: Microsatellite instability (MSI) and aneuploidy are inversely related phenomena. We tested whether ploidy status influences the clinical impact of MSI in endometrioid endometrial cancer (EEC). We analyzed 167 EECs for MSI and ploidy. Tumors were classified in three categories according to MSI and ploidy status. Associations with clinicopathological and molecular variables, survival, and treatment response were assessed.All MSI tumors (23%) were scored as diploid, and 14% of microsatellite stable (MSS) tumors presented aneuploidy. MSI tumors associated with older age at diagnosis, non-obesity, high histological grade, and advanced surgical stage. MSS-aneuploid tumors also associated with higher grade and advanced stage. In multivariate survival analysis MSI did not influence disease-free survival (DFS) or cancer-specific survival (CSS). However, when just diploid tumors were considered for the analysis, MSI significantly contributed to worse DFS and CSS, and the same was observed for aneuploidy when MSS tumors were analyzed alone. In diploid tumors, a differential response to postoperative radiotherapy (RT) was observed according to MSI, since it predicted poor DFS and CSS in the multivariate analysis.We conclude that ploidy status influences the clinical impact of MSI in EEC. Among diploid tumors those with MSI have poor clinical outcome and respond worse to RT.
ISSN: 1949-2553
DOI: 10.18632/oncotarget.2187
Source: Oncotarget[ISSN 1949-2553],v. 5 (15), p. 6206-6217
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