Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47273
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dc.contributor.authorBilbao-Sieyro, Cristinaen_US
dc.contributor.authorRamírez-Moreno, Raquelen_US
dc.contributor.authorRodríguez-González, Germánen_US
dc.contributor.authorFalcón, Orlandoen_US
dc.contributor.authorLeón, Laureanoen_US
dc.contributor.authorTorres, Santiagoen_US
dc.contributor.authorFernández, Leandroen_US
dc.contributor.authorAlonso, Sergioen_US
dc.contributor.authorDíaz-Chico, Nicolásen_US
dc.contributor.authorPerucho, Manuelen_US
dc.contributor.authorDiaz-Chico, Juan Carlosen_US
dc.contributor.otherBILBAO SIEYRO, CRISTINA-
dc.contributor.otherDiaz-Chico, Juan-
dc.contributor.otherAlonso, Sergio-
dc.contributor.otherFernandez-Perez, Leandro-
dc.contributor.otherRamirez-Moreno, Raquel-
dc.date.accessioned2018-11-23T12:13:34Z-
dc.date.available2018-11-23T12:13:34Z-
dc.date.issued2014en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://hdl.handle.net/10553/47273-
dc.description.abstractMicrosatellite instability (MSI) and aneuploidy are inversely related phenomena. We tested whether ploidy status influences the clinical impact of MSI in endometrioid endometrial cancer (EEC). We analyzed 167 EECs for MSI and ploidy. Tumors were classified in three categories according to MSI and ploidy status. Associations with clinicopathological and molecular variables, survival, and treatment response were assessed.All MSI tumors (23%) were scored as diploid, and 14% of microsatellite stable (MSS) tumors presented aneuploidy. MSI tumors associated with older age at diagnosis, non-obesity, high histological grade, and advanced surgical stage. MSS-aneuploid tumors also associated with higher grade and advanced stage. In multivariate survival analysis MSI did not influence disease-free survival (DFS) or cancer-specific survival (CSS). However, when just diploid tumors were considered for the analysis, MSI significantly contributed to worse DFS and CSS, and the same was observed for aneuploidy when MSS tumors were analyzed alone. In diploid tumors, a differential response to postoperative radiotherapy (RT) was observed according to MSI, since it predicted poor DFS and CSS in the multivariate analysis.We conclude that ploidy status influences the clinical impact of MSI in EEC. Among diploid tumors those with MSI have poor clinical outcome and respond worse to RT.en_US
dc.languageengen_US
dc.relation.ispartofOncotargeten_US
dc.sourceOncotarget[ISSN 1949-2553],v. 5 (15), p. 6206-6217en_US
dc.subject32 Ciencias médicasen_US
dc.subject320101 Oncologíaen_US
dc.subject.otherAdenomatous-Polyposis-Colien_US
dc.subject.otherDna Mismatch Repairen_US
dc.subject.otherColorectal-Canceren_US
dc.subject.otherPromoter Hypermethylationen_US
dc.subject.otherCarcinomaen_US
dc.subject.otherExpressionen_US
dc.subject.otherGeneen_US
dc.subject.otherSurvivalen_US
dc.subject.otherMethylationen_US
dc.subject.otherMutationsen_US
dc.titleMicrosatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial canceren_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.18632/oncotarget.2187en_US
dc.identifier.scopus84906271940-
dc.identifier.isi000347919500028-
dcterms.isPartOfOncotarget
dcterms.sourceOncotarget[ISSN 1949-2553],v. 5 (15), p. 6206-6217
dc.contributor.authorscopusid56294291600-
dc.contributor.authorscopusid25959711200-
dc.contributor.authorscopusid55863671600-
dc.contributor.authorscopusid6603752888-
dc.contributor.authorscopusid19234933700-
dc.contributor.authorscopusid57192268038-
dc.contributor.authorscopusid7202848203-
dc.contributor.authorscopusid12771069700-
dc.contributor.authorscopusid25723175700-
dc.contributor.authorscopusid7006337861-
dc.contributor.authorscopusid6701492347-
dc.description.lastpage6217en_US
dc.description.firstpage6206en_US
dc.relation.volume5en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000347919500028-
dc.contributor.daisngid2205075-
dc.contributor.daisngid2567033-
dc.contributor.daisngid6277767-
dc.contributor.daisngid2891739-
dc.contributor.daisngid1217537-
dc.contributor.daisngid5422159-
dc.contributor.daisngid2199904-
dc.contributor.daisngid30389612-
dc.contributor.daisngid795544-
dc.contributor.daisngid964210-
dc.contributor.daisngid32610420-
dc.contributor.daisngid16324726-
dc.contributor.daisngid348212-
dc.contributor.daisngid749099-
dc.identifier.investigatorRIDR-6779-2018-
dc.identifier.investigatorRIDH-1527-2015-
dc.identifier.investigatorRIDG-5145-2011-
dc.identifier.investigatorRIDH-1493-2015-
dc.identifier.investigatorRIDJ-4905-2018-
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Bilbao-Sieyro, C-
dc.contributor.wosstandardWOS:Ramirez-Moreno, R-
dc.contributor.wosstandardWOS:Rodriguez-Gonzalez, G-
dc.contributor.wosstandardWOS:Falcon, O-
dc.contributor.wosstandardWOS:Leon, L-
dc.contributor.wosstandardWOS:Torres, S-
dc.contributor.wosstandardWOS:Fernandez, L-
dc.contributor.wosstandardWOS:Alonso, S-
dc.contributor.wosstandardWOS:Daiz-Chico, N-
dc.contributor.wosstandardWOS:Perucho, M-
dc.contributor.wosstandardWOS:Diaz-Chico, JC-
dc.date.coverdateEnero 2014en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,521
dc.description.jcr6,359
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-4796-1445-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBilbao Sieyro, Cristina-
crisitem.author.fullNameRamirez Moreno,Raquel-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
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