Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/47273
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dc.contributor.authorBilbao-Sieyro, Cristina
dc.contributor.authorRamírez-Moreno, Raquel
dc.contributor.authorRodríguez-González, Germán
dc.contributor.authorFalcón, Orlando
dc.contributor.authorLeón, Laureano
dc.contributor.authorTorres, Santiago
dc.contributor.authorFernández, Leandro
dc.contributor.authorAlonso, Sergio
dc.contributor.authorDíaz-Chico, Nicolás
dc.contributor.authorPerucho, Manuel
dc.contributor.authorDiaz-Chico, Juan Carlos
dc.contributor.otherBILBAO SIEYRO, CRISTINA
dc.contributor.otherDiaz-Chico, Juan
dc.contributor.otherAlonso, Sergio
dc.contributor.otherFernandez-Perez, Leandro
dc.contributor.otherRamirez-Moreno, Raquel
dc.date.accessioned2018-11-23T12:13:34Z-
dc.date.available2018-11-23T12:13:34Z-
dc.date.issued2014
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/10553/47273-
dc.description.abstractMicrosatellite instability (MSI) and aneuploidy are inversely related phenomena. We tested whether ploidy status influences the clinical impact of MSI in endometrioid endometrial cancer (EEC). We analyzed 167 EECs for MSI and ploidy. Tumors were classified in three categories according to MSI and ploidy status. Associations with clinicopathological and molecular variables, survival, and treatment response were assessed.All MSI tumors (23%) were scored as diploid, and 14% of microsatellite stable (MSS) tumors presented aneuploidy. MSI tumors associated with older age at diagnosis, non-obesity, high histological grade, and advanced surgical stage. MSS-aneuploid tumors also associated with higher grade and advanced stage. In multivariate survival analysis MSI did not influence disease-free survival (DFS) or cancer-specific survival (CSS). However, when just diploid tumors were considered for the analysis, MSI significantly contributed to worse DFS and CSS, and the same was observed for aneuploidy when MSS tumors were analyzed alone. In diploid tumors, a differential response to postoperative radiotherapy (RT) was observed according to MSI, since it predicted poor DFS and CSS in the multivariate analysis.We conclude that ploidy status influences the clinical impact of MSI in EEC. Among diploid tumors those with MSI have poor clinical outcome and respond worse to RT.
dc.relation.ispartofOncotarget
dc.sourceOncotarget[ISSN 1949-2553],v. 5 (15), p. 6206-6217
dc.subject.otherAdenomatous-Polyposis-Coli
dc.subject.otherDna Mismatch Repair
dc.subject.otherColorectal-Cancer
dc.subject.otherPromoter Hypermethylation
dc.subject.otherCarcinoma
dc.subject.otherExpression
dc.subject.otherGene
dc.subject.otherSurvival
dc.subject.otherMethylation
dc.subject.otherMutations
dc.titleMicrosatellite instability and ploidy status define three categories with distinctive prognostic impact in endometrioid endometrial cancer
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.18632/oncotarget.2187
dc.identifier.scopus84906271940
dc.identifier.isi000347919500028
dcterms.isPartOfOncotarget
dcterms.sourceOncotarget[ISSN 1949-2553],v. 5 (15), p. 6206-6217
dc.contributor.authorscopusid56294291600
dc.contributor.authorscopusid25959711200
dc.contributor.authorscopusid55863671600
dc.contributor.authorscopusid6603752888
dc.contributor.authorscopusid19234933700
dc.contributor.authorscopusid57192268038
dc.contributor.authorscopusid7202848203
dc.contributor.authorscopusid12771069700
dc.contributor.authorscopusid25723175700
dc.contributor.authorscopusid7006337861
dc.contributor.authorscopusid6701492347
dc.description.lastpage6217
dc.description.firstpage6206
dc.relation.volume5
dc.type2Artículoes
dc.identifier.wosWOS:000347919500028
dc.contributor.daisngid2205075
dc.contributor.daisngid2567033
dc.contributor.daisngid6277767
dc.contributor.daisngid2891739
dc.contributor.daisngid1217537
dc.contributor.daisngid5422159
dc.contributor.daisngid2199904
dc.contributor.daisngid30389612
dc.contributor.daisngid795544
dc.contributor.daisngid964210
dc.contributor.daisngid32610420
dc.contributor.daisngid16324726
dc.contributor.daisngid348212
dc.contributor.daisngid749099
dc.identifier.investigatorRIDR-6779-2018
dc.identifier.investigatorRIDH-1527-2015
dc.identifier.investigatorRIDG-5145-2011
dc.identifier.investigatorRIDH-1493-2015
dc.identifier.investigatorRIDJ-4905-2018
dc.contributor.wosstandardWOS:Bilbao-Sieyro, C
dc.contributor.wosstandardWOS:Ramirez-Moreno, R
dc.contributor.wosstandardWOS:Rodriguez-Gonzalez, G
dc.contributor.wosstandardWOS:Falcon, O
dc.contributor.wosstandardWOS:Leon, L
dc.contributor.wosstandardWOS:Torres, S
dc.contributor.wosstandardWOS:Fernandez, L
dc.contributor.wosstandardWOS:Alonso, S
dc.contributor.wosstandardWOS:Daiz-Chico, N
dc.contributor.wosstandardWOS:Perucho, M
dc.contributor.wosstandardWOS:Diaz-Chico, JC
dc.date.coverdateEnero 2014
dc.identifier.ulpgces
dc.description.sjr2,521
dc.description.jcr6,359
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptMorfología-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-4796-1445-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.orcid0000-0002-0944-990X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBilbao Sieyro, Cristina-
crisitem.author.fullNameRamírez Moreno, Raquel-
crisitem.author.fullNameFernández Pérez, Leandro Fco-
crisitem.author.fullNameDíaz Chico, Juan Carlos-
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