Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43486
Title: Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents
Authors: Rubio Sánchez, Sara 
Quintana Aguiar, José Martín 
López, Mariana
Eiroa, José Luis 
Triana, Jorge
Estévez Rosas, Francisco Jesús 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Apoptosis
Flavonoids
Cytotoxic activity
Caspases
DNA fragmentation, et al
Issue Date: 2006
Publisher: 0014-2999
Project: Nuevos Compuestos Antileucémicos 
Journal: European journal of pharmacology 
Abstract: We have analyzed the cytotoxicity of 22 compounds with a phenylbenzo-gamma-pirone core structure, most of them obtained from natural sources, in five human tumor cell lines (HL-60, A431, SK-OV-3, HeLa and HOS). Betuletol 3-methyl ether and its diacetate were the most cytotoxic compounds. The HL-60 cell line was especially sensitive to these compounds, with IC50 values of approximately 1 microM. Treatment of HL-60 cells with betuletol 3-methyl ether was associated with apoptosis induction which was prevented by a non-specific caspase inhibitor (z-VAD-fmk) and also by a specific inhibitor of caspase-8 (z-IETD-fmk) indicating activation of the extrinsic apoptotic pathway. The results suggest that betuletol 3-methyl ether has potential as new anticancer agent.
URI: http://hdl.handle.net/10553/43486
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2006.07.020
Source: European Journal of Pharmacology [ISSN 0014-2999], v. 548, p. 9-20
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

35
checked on Jun 13, 2021

WEB OF SCIENCETM
Citations

39
checked on Jun 13, 2021

Page view(s)

28
checked on Jun 13, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.