Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43486
Título: Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents
Autores/as: Rubio Sánchez, Sara 
Quintana Aguiar, José Martín 
López, Mariana
Eiroa, José Luis 
Triana, Jorge
Estévez Rosas, Francisco Jesús 
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Apoptosis
Flavonoids
Cytotoxic activity
Caspases
DNA fragmentation, et al.
Fecha de publicación: 2006
Editor/a: 0014-2999
Proyectos: Nuevos Compuestos Antileucémicos 
Publicación seriada: European journal of pharmacology 
Resumen: We have analyzed the cytotoxicity of 22 compounds with a phenylbenzo-gamma-pirone core structure, most of them obtained from natural sources, in five human tumor cell lines (HL-60, A431, SK-OV-3, HeLa and HOS). Betuletol 3-methyl ether and its diacetate were the most cytotoxic compounds. The HL-60 cell line was especially sensitive to these compounds, with IC50 values of approximately 1 microM. Treatment of HL-60 cells with betuletol 3-methyl ether was associated with apoptosis induction which was prevented by a non-specific caspase inhibitor (z-VAD-fmk) and also by a specific inhibitor of caspase-8 (z-IETD-fmk) indicating activation of the extrinsic apoptotic pathway. The results suggest that betuletol 3-methyl ether has potential as new anticancer agent.
URI: http://hdl.handle.net/10553/43486
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2006.07.020
Fuente: European Journal of Pharmacology [ISSN 0014-2999], v. 548, p. 9-20
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