Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43486
DC FieldValueLanguage
dc.contributor.authorRubio Sánchez, Saraen_US
dc.contributor.authorQuintana Aguiar, José Martínen_US
dc.contributor.authorLópez, Marianaen_US
dc.contributor.authorEiroa, José Luisen_US
dc.contributor.authorTriana, Jorgeen_US
dc.contributor.authorEstévez Rosas, Francisco Jesúsen_US
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherRubio, Sara-
dc.contributor.otherQuintana, Jose-
dc.contributor.otherRubio Sánchez, Sara-
dc.date.accessioned2018-11-21T15:32:45Z-
dc.date.available2018-11-21T15:32:45Z-
dc.date.issued2006en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10553/43486-
dc.description.abstractWe have analyzed the cytotoxicity of 22 compounds with a phenylbenzo-gamma-pirone core structure, most of them obtained from natural sources, in five human tumor cell lines (HL-60, A431, SK-OV-3, HeLa and HOS). Betuletol 3-methyl ether and its diacetate were the most cytotoxic compounds. The HL-60 cell line was especially sensitive to these compounds, with IC50 values of approximately 1 microM. Treatment of HL-60 cells with betuletol 3-methyl ether was associated with apoptosis induction which was prevented by a non-specific caspase inhibitor (z-VAD-fmk) and also by a specific inhibitor of caspase-8 (z-IETD-fmk) indicating activation of the extrinsic apoptotic pathway. The results suggest that betuletol 3-methyl ether has potential as new anticancer agent.en_US
dc.languageengen_US
dc.publisher0014-2999-
dc.relationNuevos Compuestos Antileucémicosen_US
dc.relation.ispartofEuropean journal of pharmacologyen_US
dc.sourceEuropean Journal of Pharmacology [ISSN 0014-2999], v. 548, p. 9-20en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherApoptosisen_US
dc.subject.otherFlavonoidsen_US
dc.subject.otherCytotoxic activityen_US
dc.subject.otherCaspasesen_US
dc.subject.otherDNA fragmentationen_US
dc.subject.otherPoly(ADP-ribose) polymeraseen_US
dc.titlePhenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agentsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejphar.2006.07.020en_US
dc.identifier.scopus33748704067-
dc.identifier.isi000241172600002-
dcterms.isPartOfEuropean Journal Of Pharmacology-
dcterms.sourceEuropean Journal Of Pharmacology[ISSN 0014-2999],v. 548 (1-3), p. 9-20-
dc.contributor.authorscopusid22635323400-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid22985994700-
dc.contributor.authorscopusid6507583429-
dc.contributor.authorscopusid6602859915-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage20en_US
dc.description.firstpage9en_US
dc.relation.volume548en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000241172600002-
dc.contributor.daisngid4276242-
dc.contributor.daisngid128315-
dc.contributor.daisngid5158464-
dc.contributor.daisngid2831014-
dc.contributor.daisngid1400733-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-4656-2013-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDNo ID-
dc.contributor.wosstandardWOS:Rubio, S-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Lopez, M-
dc.contributor.wosstandardWOS:Eiroa, JL-
dc.contributor.wosstandardWOS:Triana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateOctubre 2006en_US
dc.identifier.ulpgces
dc.description.jcr2,522
dc.description.jcrqQ2
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptQuímica-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0001-7633-1285-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-4986-8332-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRubio Sánchez, Sara-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEiroa Martínez, José Luis-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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