Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/41858
Title: Effect of leukocyte-reduced platelet-rich plasma on osteoarthritis caused by cranial cruciate ligament rupture: A canine gait analysis model
Authors: Vilar, José M. 
Manera, Maria E.
Santana, Angelo 
Spinella, Giuseppe
Rodríguez Lozano, David Oliverio 
Rubio, Mónica
Carrillo, José M.
Sopena, Joaquín
Batista, Miguel 
UNESCO Clasification: 3109 Ciencias veterinarias
120903 Análisis de datos
240401 Bioestadística
Keywords: Dogs
Deficiency
Efficacy
Therapy
Disease, et al
Issue Date: 2018
Journal: PLoS ONE 
Abstract: The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals. Ten untreated, sound English bulldogs were used as a reference group. Clinical outcomes were evaluated using a linear mixed effects model. Mean values of PVF, VI, ST, and AROM were improved within the first 3 months post-treatment in the CCLR group, with mean measured changes increasing to maximum 4.56% body weight gain, 1.5% body weight/second, 0.07 seconds, and 6.18 degrees, respectively. The effects declined progressively after the treatment interval, ending at nearly initial levels after 6 months. This study demonstrates that dogs with CCLR treated with intra-articular PRP had improved PVF, VI, ST, and AROM over time; the duration of effect was waning by the end of the post-treatment period.
URI: http://hdl.handle.net/10553/41858
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0194752
Source: PLoS ONE [ISSN 1932-6203], v. 13 (3)
Appears in Collections:Artículos
Thumbnail
Adobe PDF (3,57 MB)
Show full item record

SCOPUSTM   
Citations

7
checked on May 2, 2021

WEB OF SCIENCETM
Citations

6
checked on May 2, 2021

Page view(s)

39
checked on May 2, 2021

Download(s)

42
checked on May 2, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.