Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/41858
Título: Effect of leukocyte-reduced platelet-rich plasma on osteoarthritis caused by cranial cruciate ligament rupture: A canine gait analysis model
Autores/as: Vilar, José M. 
Manera, Maria E.
Santana, Angelo 
Spinella, Giuseppe
Rodríguez Lozano, David Oliverio 
Rubio, Mónica
Carrillo, José M.
Sopena, Joaquín
Batista, Miguel 
Clasificación UNESCO: 3109 Ciencias veterinarias
120903 Análisis de datos
240401 Bioestadística
Palabras clave: Dogs
Deficiency
Efficacy
Therapy
Disease, et al.
Fecha de publicación: 2018
Publicación seriada: PLoS ONE 
Resumen: The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals. Ten untreated, sound English bulldogs were used as a reference group. Clinical outcomes were evaluated using a linear mixed effects model. Mean values of PVF, VI, ST, and AROM were improved within the first 3 months post-treatment in the CCLR group, with mean measured changes increasing to maximum 4.56% body weight gain, 1.5% body weight/second, 0.07 seconds, and 6.18 degrees, respectively. The effects declined progressively after the treatment interval, ending at nearly initial levels after 6 months. This study demonstrates that dogs with CCLR treated with intra-articular PRP had improved PVF, VI, ST, and AROM over time; the duration of effect was waning by the end of the post-treatment period.
URI: http://hdl.handle.net/10553/41858
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0194752
Fuente: PLoS ONE [ISSN 1932-6203], v. 13 (3)
Colección:Artículos
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