Salicylate decreases production of AmpC type β-lactamases and increases susceptibility to β-lactams in a Morganella morganii clinical isolate

Título:	Salicylate decreases production of AmpC type β-lactamases and increases susceptibility to β-lactams in a Morganella morganii clinical isolate
Autores/as:	Tavío, María M. Perilli, Mariagrazia Vila, Jordi Becerro, Pino Casañas, Lucía Amicosante, Gianfranco Teresa Jiménez De Anta, María
Clasificación UNESCO:	32 Ciencias médicas 320103 Microbiología clínica
Palabras clave:	Multiple Antibiotic-Resistance Enterobacter-Cloacae Escherichia-Coli Outer-Membrane Expression, et al.
Fecha de publicación:	2004
Publicación seriada:	FEMS Microbiology Letters
Resumen:	The effect of salicylate, a marRAB inducer, on the resistance to beta-lactams was characterized in an AmpC beta-lactamase hyperproducer Morganella morganii clinical isolate (the M1 strain). Results were compared with those of the effect of salicylate in a wild-type M. morganii strain. Salicylate induced a decreased susceptibility to nalidixic acid, norfloxacin and tetracycline and simultaneously increased the susceptibility to beta-lactams apparently due to the repression of AmpC P-lactamase synthesis in the M1 strain. Likewise, salicylate only repressed 46 kDa outer membrane protein expression in the wild-type strain, since the clinical isolate M1 did not express it.
URI:	http://hdl.handle.net/10553/49971
ISSN:	0378-1097
DOI:	10.1016/j.femsle.2004.07.030
Fuente:	FEMS Microbiology Letters[ISSN 0378-1097],v. 238(1), p. 139-144 (Septiembre 2004)
Colección:	Artículos

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