Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/49971
Title: Salicylate decreases production of AmpC type β-lactamases and increases susceptibility to β-lactams in a Morganella morganii clinical isolate
Authors: Tavío, María M. 
Perilli, Mariagrazia
Vila, Jordi
Becerro, Pino
Casañas, Lucía
Amicosante, Gianfranco
Teresa Jiménez De Anta, María
Keywords: Multiple Antibiotic-Resistance
Enterobacter-Cloacae
Escherichia-Coli
Outer-Membrane
Expression
Proteus
Porins
Issue Date: 2004
Publisher: 0378-1097
Journal: FEMS Microbiology Letters 
Abstract: The effect of salicylate, a marRAB inducer, on the resistance to beta-lactams was characterized in an AmpC beta-lactamase hyperproducer Morganella morganii clinical isolate (the M1 strain). Results were compared with those of the effect of salicylate in a wild-type M. morganii strain. Salicylate induced a decreased susceptibility to nalidixic acid, norfloxacin and tetracycline and simultaneously increased the susceptibility to beta-lactams apparently due to the repression of AmpC P-lactamase synthesis in the M1 strain. Likewise, salicylate only repressed 46 kDa outer membrane protein expression in the wild-type strain, since the clinical isolate M1 did not express it. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/10553/49971
ISSN: 0378-1097
DOI: 10.1016/j.femsle.2004.07.030
Source: FEMS Microbiology Letters[ISSN 0378-1097],v. 238, p. 139-144
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