Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/49502
Título: Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing
Autores/as: Lopez-Miranda, Jose
Kam, Nathan
Osada, Jesus
Rodriguez, Carmen
Fernandez, Pilar 
Contois, John
Schaefer, Ernst J.
Ordovas, Jose M.
Clasificación UNESCO: 32 Ciencias médicas
2302 Bioquímica
Palabras clave: Apolipoprotein
Apolipoprotein B
Intestine
mRNA
Postprandial
Fecha de publicación: 1994
Publicación seriada: Biochimica et biophysica acta. L, Lipids and lipid metabolism 
Resumen: Our purpose was to assess the effect of a fat-rich meal on intestinal apolipoprotein B (apoB) mRNA levels and editing. We obtained jejunal biopsies from eight healthy adults in the fasting state and 3 h after a meal containing 1 g/kg of fat. In the fasting state, 93% of the apoB mRNA contained the editing sequence resulting in apoB-48 production. Feeding induced no significant changes in apoB mRNA levels or editing. Our data are consistent with the concept that the significant increase in apoB-48 within triglyceride-rich lipoproteins in postprandial plasma is not due to alterations in apoB gene expression or editing.
URI: http://hdl.handle.net/10553/49502
ISSN: 0005-2760
DOI: 10.1016/0005-2760(94)90038-8
Fuente: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism[ISSN 0005-2760],v. 1214, p. 143-147
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