Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing

Título:	Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing
Autores/as:	Lopez-Miranda, Jose Kam, Nathan Osada, Jesus Rodriguez, Carmen Fernandez, Pilar Contois, John Schaefer, Ernst J. Ordovas, Jose M.
Clasificación UNESCO:	32 Ciencias médicas 2302 Bioquímica
Palabras clave:	Apolipoprotein Apolipoprotein B Intestine mRNA Postprandial
Fecha de publicación:	1994
Publicación seriada:	Biochimica et biophysica acta. L, Lipids and lipid metabolism
Resumen:	Our purpose was to assess the effect of a fat-rich meal on intestinal apolipoprotein B (apoB) mRNA levels and editing. We obtained jejunal biopsies from eight healthy adults in the fasting state and 3 h after a meal containing 1 g/kg of fat. In the fasting state, 93% of the apoB mRNA contained the editing sequence resulting in apoB-48 production. Feeding induced no significant changes in apoB mRNA levels or editing. Our data are consistent with the concept that the significant increase in apoB-48 within triglyceride-rich lipoproteins in postprandial plasma is not due to alterations in apoB gene expression or editing.
URI:	http://hdl.handle.net/10553/49502
ISSN:	0005-2760
DOI:	10.1016/0005-2760(94)90038-8
Fuente:	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism[ISSN 0005-2760],v. 1214, p. 143-147
Colección:	Artículos

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