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http://hdl.handle.net/10553/120637
| Título: | Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease | Autores/as: | Gutierrez, Alejandro H. Mazariegos, Marina S. Alemany, Susana Nevzorova, Yulia A. Cubero, Francisco Javier Sanz-García, Carlos |
Clasificación UNESCO: | 32 Ciencias médicas 320713 Oncología 2302 Bioquímica |
Palabras clave: | Cancer Cancer Osaka Thyroid Chronic Liver Disease Inflammation Mapk, et al. |
Fecha de publicación: | 2023 | Publicación seriada: | Biochimica et Biophysica Acta - Molecular Basis of Disease | Resumen: | The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD. | URI: | http://hdl.handle.net/10553/120637 | ISSN: | 0925-4439 | DOI: | 10.1016/j.bbadis.2023.166660 | Fuente: | Biochimica et Biophysica Acta - Molecular Basis of Disease [ISSN 0925-4439], v. 1869 (4): 166660, (Abril 2023) |
| Colección: | Artículos |
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