Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/118738
| Título: | R5020 enhances PGE2 stimulated steroidogenesis in cultured rat granulosa cells | Autores/as: | Fanjul Rodríguez, Luisa Fernanda Gonzalez, J. Saavedra Santana, Pedro Estévez Rosas, Francisco Jesús Quintana, J. Ruiz De Galarreta Hernandez,C. Manuel |
Clasificación UNESCO: | 32 Ciencias médicas 320102 Genética clínica |
Palabras clave: | Steroidogenesis Granulosa cells Rat Human Chorionic-Gonadotropin Progesterone Production, et al. |
Fecha de publicación: | 1992 | Publicación seriada: | Revista Espanola de Fisiologia | Resumen: | Progesterone biosynthesis and metabolization to 20alpha-hydroxyprogesterone was stimulated in granulosa cells cultured in the presence of 20 ng/ml of follicle stimulating hormone (FSH) or increasing concentrations of PGE2 (10(-9)-10(-7) M). Concurrent treatment with the synthetic progestin R5020 (10(-6) M) enhanced the FSH or PGE2 stimulated progesterone and 20alpha-hydroxyprogesterone accumulation in culture media, as well as DELTA5-3beta-hydroxysteroid dehydrogenase activity in granulosa cell homogenates. These findings may represent another example of an autocrine control mechanism in which the steroidogenic product of the granulosa cell exerts an ultra-short loop regulation of its own production. | ISSN: | 0034-9402 | Fuente: | Revista Espanola De Fisiologia[ISSN 0034-9402],v. 48 (3), p. 167-170 (Diciembre 1992) |
| Colección: | Artículos |
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