Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/8999
Title: MVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapy
Authors: Henríquez Hernández, Luis Alberto 
Moreno, Mercedes
Rey, Agustín
Lloret Saez-Bravo, Marta 
Lara Jiménez, Pedro Carlos 
UNESCO Clasification: 320101 Oncología
Keywords: MVP
IGF-1R
Oral carcinoma
Radiotherapy
Predictive factor
Issue Date: 2012
Journal: Radiation Oncology 
Abstract: Objective: To explore the role of Major Vault Protein (MVP) in oral cavity squamous cell carcinoma patients. Subjects and Methods: 131 consecutive patients suffering from oral cavity squamous cell carcinoma were included in the study. In the whole series, the mean follow-up for survivors was 123.11 ± 40.36 months. Patients in tumour stages I and II were referred to surgery; patients in stage III-IV to postoperative radiotherapy (mean dose = 62.13 ± 7.74 Gy in 1.8–2 Gy/fraction). MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue. Results: MVP expression was positive in 112 patients (85.5%) and no relation was found with clinic pathological variables. MVP overexpression (those tumours with moderate or strong expression of the protein) was related to insulin-like growth factor receptor-1 (IGF-1R) expression (P = 0.014). Tumour stage of the disease was the most important prognostic factor related to survival. Tumours overexpressing MVP and IGF-1R were strongly related to poor disease-free survival (P = 0.008, Exp(B) = 2.730, CI95% (1.302-5.724)) and cause-specific survival (P = 0.014, Exp(B) = 2.570, CI95% (1.215-5.437)) in patients achieving tumour stages III-IV, in multivariate analysis. Conclusions: MVP and IGF-1R expression were related in oral squamous cell carcinoma and conferred reduced long-term survival in patients suffering from advanced stages of the disease.
URI: http://hdl.handle.net/10553/8999
Other Identifiers: http://dx.doi.org/10.1186/1748-717X-7-147
DOI: 10.1186/1748-717X-7-147
Source: Radiation Oncology 2012
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