Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/8999
DC FieldValueLanguage
dc.contributor.authorHenríquez Hernández, Luis Albertoen_US
dc.contributor.authorMoreno, Mercedesen_US
dc.contributor.authorRey, Agustínen_US
dc.contributor.authorLloret Saez-Bravo, Martaen_US
dc.contributor.authorLara Jiménez, Pedro Carlosen_US
dc.date.accessioned2012-11-12T08:55:41Z-
dc.date.accessioned2018-04-25T13:58:55Z-
dc.date.available2012-11-12T08:55:41Z-
dc.date.available2018-04-25T13:58:55Z-
dc.date.issued2012en_US
dc.identifierhttp://dx.doi.org/10.1186/1748-717X-7-147-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/8999-
dc.description.abstractObjective: To explore the role of Major Vault Protein (MVP) in oral cavity squamous cell carcinoma patients. Subjects and Methods: 131 consecutive patients suffering from oral cavity squamous cell carcinoma were included in the study. In the whole series, the mean follow-up for survivors was 123.11 ± 40.36 months. Patients in tumour stages I and II were referred to surgery; patients in stage III-IV to postoperative radiotherapy (mean dose = 62.13 ± 7.74 Gy in 1.8–2 Gy/fraction). MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue. Results: MVP expression was positive in 112 patients (85.5%) and no relation was found with clinic pathological variables. MVP overexpression (those tumours with moderate or strong expression of the protein) was related to insulin-like growth factor receptor-1 (IGF-1R) expression (P = 0.014). Tumour stage of the disease was the most important prognostic factor related to survival. Tumours overexpressing MVP and IGF-1R were strongly related to poor disease-free survival (P = 0.008, Exp(B) = 2.730, CI95% (1.302-5.724)) and cause-specific survival (P = 0.014, Exp(B) = 2.570, CI95% (1.215-5.437)) in patients achieving tumour stages III-IV, in multivariate analysis. Conclusions: MVP and IGF-1R expression were related in oral squamous cell carcinoma and conferred reduced long-term survival in patients suffering from advanced stages of the disease.en_US
dc.languageengen_US
dc.relation.ispartofRadiation Oncologyen_US
dc.sourceRadiation Oncology 2012en_US
dc.subject320101 Oncologíaen_US
dc.subject.otherMVPen_US
dc.subject.otherIGF-1Ren_US
dc.subject.otherOral carcinomaen_US
dc.subject.otherRadiotherapyen_US
dc.subject.otherPredictive factoren_US
dc.titleMVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1748-717X-7-147en_US
dc.identifier.scopus2-s2.0-84868693748-
dc.identifier.isi000311416700001-
dc.date.updated2012-11-09T07:46:18Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066en-
dc.rights.holderLuis Henríquez-Hernández et al.; licensee BioMed Central Ltd.-
dc.compliance.driver1-
dc.contributor.authorscopusid15829708200-
dc.contributor.authorscopusid56328294100-
dc.contributor.authorscopusid7202860969-
dc.contributor.authorscopusid7003855087-
dc.contributor.authorscopusid7004374085-
dc.identifier.eissn1748-717X-
dc.identifier.issue1-
dc.relation.volume7en_US
dc.investigacionCiencias de la Saluden_US
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.type2Artículoen_US
dc.contributor.daisngid465624-
dc.contributor.daisngid3955607-
dc.contributor.daisngid4381521-
dc.contributor.daisngid802813-
dc.contributor.daisngid591076-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA-
dc.contributor.wosstandardWOS:Moreno, M-
dc.contributor.wosstandardWOS:Rey, A-
dc.contributor.wosstandardWOS:Lloret, M-
dc.contributor.wosstandardWOS:Lara, PC-
dc.date.coverdateAgosto 2012en_US
dc.identifier.supplementhttp://dx.doi.org/10.1186/1748-717X-7-147-
dc.identifier.ulpgces
dc.description.sjr1,04
dc.description.jcr2,107
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameLloret Sáez-Bravo, Marta-
crisitem.author.fullNameLara Jiménez, Pedro Carlos-
Appears in Collections:Artículos
Thumbnail
Adobe PDF (601,21 kB)
XML (50,51 kB)
Show simple item record

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.