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Title: Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial
Authors: Hernáez, Álvaro
Lassale, Camille
Castro-Barquero, Sara
Ros, Emilio
Tresserra-Rimbau, Anna
Castañer, Olga
Pintó, Xavier
Vázquez-Ruiz, Zenaida
Sorlí, José V.
Salas-Salvadó, Jordi
Lapetra, José
Gómez-Gracia, Enrique
Alonso-Gómez, Ángel M.
Fiol, Miquel
Serra Majem, Luis 
Sacanella, Emilio
Razquin, Cristina
Corella, Dolores
Guasch-Ferré, Marta
Cofán, Montserrat
Estruch, Ramón
UNESCO Clasification: 320501 Cardiología
320502 Endocrinología
Keywords: Mediterranean Diet
Platelet Count
Randomized Controlled Trial
Issue Date: 2021
Journal: Nutrients 
Abstract: There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
DOI: 10.3390/nu13020559
Source: Nutrients [EISSN 2072-6643], v. 13 (2), p. 1-13, (Febrero 2021)
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