Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/77801
Campo DC Valoridioma
dc.contributor.authorHernáez, Álvaroen_US
dc.contributor.authorLassale, Camilleen_US
dc.contributor.authorCastro-Barquero, Saraen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorTresserra-Rimbau, Annaen_US
dc.contributor.authorCastañer, Olgaen_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorVázquez-Ruiz, Zenaidaen_US
dc.contributor.authorSorlí, José V.en_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorAlonso-Gómez, Ángel M.en_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorSerra Majem, Luisen_US
dc.contributor.authorSacanella, Emilioen_US
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorCofán, Montserraten_US
dc.contributor.authorEstruch, Ramónen_US
dc.date.accessioned2021-02-22T15:05:07Z-
dc.date.available2021-02-22T15:05:07Z-
dc.date.issued2021en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/77801-
dc.description.abstractThere is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.en_US
dc.languageengen_US
dc.relation.ispartofNutrientsen_US
dc.sourceNutrients [EISSN 2072-6643], v. 13 (2), p. 1-13, (Febrero 2021)en_US
dc.subject320501 Cardiologíaen_US
dc.subject320502 Endocrinologíaen_US
dc.subject.otherMediterranean Dieten_US
dc.subject.otherPlatelet Counten_US
dc.subject.otherPreventionen_US
dc.subject.otherRandomized Controlled Trialen_US
dc.subject.otherThrombocytopeniaen_US
dc.titleMediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trialen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/nu13020559en_US
dc.identifier.scopus85100548480-
dc.contributor.authorscopusid55916184000-
dc.contributor.authorscopusid35798512000-
dc.contributor.authorscopusid57202727634-
dc.contributor.authorscopusid57202569537-
dc.contributor.authorscopusid55510803900-
dc.contributor.authorscopusid36487707800-
dc.contributor.authorscopusid57214783328-
dc.contributor.authorscopusid57217866556-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid7003691118-
dc.contributor.authorscopusid13612519200-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid55110459200-
dc.contributor.authorscopusid6602419864-
dc.contributor.authorscopusid7005989830-
dc.identifier.eissn2072-6643-
dc.description.lastpage13en_US
dc.identifier.issue2-
dc.description.firstpage1en_US
dc.relation.volume13en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateFebrero 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,287
dc.description.jcr6,706
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,6
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
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