Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/77716
Title: The Pathology of Cetacean Morbillivirus Infection and Comorbidities in Guiana Dolphins During an Unusual Mortality Event (Brazil, 2017-2018)
Authors: Groch, K. R.
Diaz Delgado, Josue 
Santos-Neto, E. B.
Ikeda, J. M. P.
Carvalho, R. R.
Oliveira, R. B.
Guari, E. B.
Flach, L.
Sierra Pulpillo, Eva María 
Alves Godinho,Ana 
Fernández Rodríguez, Antonio Jesús 
Keid, L. B.
Soares, R. M.
Kanamura, C. T.
Favero, C.
UNESCO Clasification: 3105 Peces y fauna silvestre
240119 Zoología marina
310907 Patología
Keywords: Guiana dolphin
Paramyxoviridae
Sotalia guianensi
Toxoplasma gondii
Cetacean morbillivirus
Ciliated protozoa
Marine mammal pathology
Mycosis
Issue Date: 2020
Journal: Veterinary Pathology 
Abstract: Cetacean morbillivirus (CeMV; Paramyxoviridae) is the most significant pathogen of cetaceans worldwide. The novel “multi-host” Guiana dolphin (Sotalia guianensis; GD)-CeMV strain is reported in South American waters and infects Guiana dolphins and southern right whales (Eubalaena australis). This study aimed to describe the pathologic findings, GD-CeMV viral antigen distribution and detection by RT-PCR (reverse transcriptase polymerase chain reaction), and infectious comorbidities in 29 Guiana dolphins that succumbed during an unusual mass-mortality event in Rio de Janeiro state, Brazil, between November 2017 and March 2018. The main gross findings were lack of ingesta, pulmonary edema, ascites, icterus, hepatic lipidosis, multicentric lymphadenomegaly, as well as pneumonia, polyserositis, and multiorgan vasculitis caused by Halocercus brasiliensis. Microscopically, the primary lesions were bronchointerstitial pneumonia and multicentric lymphoid depletion. The severity and extent of the lesions paralleled the distribution and intensity of morbilliviral antigen. For the first time in cetaceans, morbilliviral antigen was detected in salivary gland, optic nerve, heart, diaphragm, parietal and visceral epithelium of glomeruli, vulva, and thyroid gland. Viral antigen within circulating leukocytes suggested this as a mechanism of dissemination within the host. Comorbidities included disseminated toxoplasmosis, mycosis, ciliated protozoosis, and bacterial disease including brucellosis. These results provide strong evidence for GD-CeMV as the main cause of this unusual mass-mortality event.
URI: http://hdl.handle.net/10553/77716
ISSN: 1544-2217
DOI: 10.1177/0300985820954550
Source: Veterinary Pathology [E1544-2217], v. 57 (6), p. 845-857
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