Please use this identifier to cite or link to this item:
Title: Stress erythropoiesis in atherogenic mice
Authors: Sánchez, Ángela
Orizaola, Marta C.
Rodríguez-Muñoz, Diego
Aranda, Ana
Castrillo, Antonio 
Alemany, Susana
UNESCO Clasification: 320704 Patología cardiovascular
Keywords: Cardiovascular diseases
Haematopoietic stem cells
Issue Date: 2020
Journal: Scientific Reports 
Abstract: Bone marrow erythropoiesis is mainly homeostatic and a demand of oxygen in tissues activates stress erythropoiesis in the spleen. Here, we show an increase in the number of circulating erythrocytes in apolipoprotein E−/− mice fed a Western high-fat diet, with similar number of circulating leukocytes and CD41+ events (platelets). Atherogenic conditions increase spleen erythropoiesis with no variations of this cell lineage in the bone marrow. Spleens from atherogenic mice show augmented number of late-stage erythroblasts and biased differentiation of progenitor cells towards the erythroid cell lineage, with an increase of CD71+CD41CD34−CD117+Sca1−Lin− cells (erythroid-primed megakaryocyte-erythroid progenitors), which is consistent with the way in which atherogenesis modifies the expression of pro-erythroid and pro-megakaryocytic genes in megakaryocyte-erythroid progenitors. These data explain the transiently improved response to an acute severe hemolytic anemia insult found in atherogenic mice in comparison to control mice, as well as the higher burst-forming unit-erythroid and colony forming unit-erythroid capacity of splenocytes from atherogenic mice. In conclusion, our work demonstrates that, along with the well stablished enhancement of monocytosis during atherogenesis, stress erythropoiesis in apolipoprotein E−/− mice fed a Western high fat diet results in increased numbers of circulating red blood cells.
ISSN: 2045-2322
DOI: 10.1038/s41598-020-74665-x
Source: Scientific Reports [EISSN 2045-2322], v. 10 (1), 18469, (Diciembre 2020)
Appears in Collections:Artículos
Adobe PDF (3,6 MB)
Show full item record

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.