Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/75483
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dc.contributor.authorSánchez, Ángelaen_US
dc.contributor.authorOrizaola, Marta C.en_US
dc.contributor.authorRodríguez-Muñoz, Diegoen_US
dc.contributor.authorAranda, Anaen_US
dc.contributor.authorCastrillo, Antonioen_US
dc.contributor.authorAlemany, Susanaen_US
dc.date.accessioned2020-11-12T18:49:27Z-
dc.date.available2020-11-12T18:49:27Z-
dc.date.issued2020en_US
dc.identifier.issn2045-2322en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/75483-
dc.description.abstractBone marrow erythropoiesis is mainly homeostatic and a demand of oxygen in tissues activates stress erythropoiesis in the spleen. Here, we show an increase in the number of circulating erythrocytes in apolipoprotein E−/− mice fed a Western high-fat diet, with similar number of circulating leukocytes and CD41+ events (platelets). Atherogenic conditions increase spleen erythropoiesis with no variations of this cell lineage in the bone marrow. Spleens from atherogenic mice show augmented number of late-stage erythroblasts and biased differentiation of progenitor cells towards the erythroid cell lineage, with an increase of CD71+CD41CD34−CD117+Sca1−Lin− cells (erythroid-primed megakaryocyte-erythroid progenitors), which is consistent with the way in which atherogenesis modifies the expression of pro-erythroid and pro-megakaryocytic genes in megakaryocyte-erythroid progenitors. These data explain the transiently improved response to an acute severe hemolytic anemia insult found in atherogenic mice in comparison to control mice, as well as the higher burst-forming unit-erythroid and colony forming unit-erythroid capacity of splenocytes from atherogenic mice. In conclusion, our work demonstrates that, along with the well stablished enhancement of monocytosis during atherogenesis, stress erythropoiesis in apolipoprotein E−/− mice fed a Western high fat diet results in increased numbers of circulating red blood cells.en_US
dc.languageengen_US
dc.relation.ispartofScientific Reportsen_US
dc.sourceScientific Reports [EISSN 2045-2322], v. 10 (1), 18469, (Diciembre 2020)en_US
dc.subject320704 Patología cardiovascularen_US
dc.subject.otherCardiovascular diseasesen_US
dc.subject.otherHaematopoietic stem cellsen_US
dc.titleStress erythropoiesis in atherogenic miceen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-020-74665-xen_US
dc.identifier.scopus85094179853-
dc.contributor.authorscopusid57219570394-
dc.contributor.authorscopusid57219606187-
dc.contributor.authorscopusid57219568800-
dc.contributor.authorscopusid57204744730-
dc.contributor.authorscopusid55445301000-
dc.contributor.authorscopusid7003796446-
dc.identifier.eissn2045-2322-
dc.identifier.issue1-
dc.relation.volume10en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2020en_US
dc.identifier.ulpgcen_US
dc.description.sjr1,24
dc.description.jcr4,379
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-2057-2159-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCastrillo Viguera,Antonio Jesús-
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