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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74714
DC FieldValueLanguage
dc.contributor.authorTena Pérez, Víctoren_US
dc.contributor.authorApaza Ticona, Luisen_US
dc.contributor.authorCabanillas, Alfredo H.en_US
dc.contributor.authorMaderuelo Corral, Santiagoen_US
dc.contributor.authorPerles, Josefinaen_US
dc.contributor.authorRosero Valencia, Diego Fernandoen_US
dc.contributor.authorMartel Quintana, Anteraen_US
dc.contributor.authorOrtega Domenech, Montserraten_US
dc.contributor.authorRumbero Sánchez, Ángelen_US
dc.date.accessioned2020-10-14T08:51:19Z-
dc.date.available2020-10-14T08:51:19Z-
dc.date.issued2020en_US
dc.identifier.issn0031-9422en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/74714-
dc.description.abstractThree carbamidocyclophanes, A, F and V, and carbamidocylindrofridin A were isolated from the cultured freshwater cyanobacterium Cylindrospermum stagnale, collected in the Canary Islands. The chemical structures of these compounds were elucidated through NMR, HRMS and ECD spectroscopy. The absolute configuration of carbamidocyclophane A was confirmed using X-ray-diffraction. All compounds showed apoptotic capacity against the SK-MEL-1, SK-MEL-28 and SK-MEL-31 tumour cells. Carbamidocylindrofridin A had the highest anti-tumour potential, with an IC50 of 1 ± 0.3 μM in the SK-MEL-1 cell line.en_US
dc.languageengen_US
dc.relation.ispartofPhytochemistryen_US
dc.sourcePhytochemistry [ISSN 0031-9422], v. 180, (Diciembre 2020)en_US
dc.subject23 Químicaen_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherAnti-Tumouren_US
dc.subject.otherCarbamidocyclophaneen_US
dc.subject.otherCarbamidocylindrofridinen_US
dc.subject.otherCyanobacteriumen_US
dc.subject.otherCylindrospermum Stagnaleen_US
dc.subject.otherNostocaceaeen_US
dc.titleAntitumoral potential of carbamidocyclophanes and carbamidocylindrofridin A isolated from the cyanobacterium Cylindrospermum stagnale BEA 0605Ben_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.phytochem.2020.112529en_US
dc.identifier.scopus85091917505-
dc.contributor.authorscopusid57197446944-
dc.contributor.authorscopusid55320647400-
dc.contributor.authorscopusid57200917147-
dc.contributor.authorscopusid57219252549-
dc.contributor.authorscopusid6507174978-
dc.contributor.authorscopusid57219252800-
dc.contributor.authorscopusid57197486214-
dc.contributor.authorscopusid57213589824-
dc.contributor.authorscopusid57199979254-
dc.relation.volume180en_US
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.utils.revisionSíen_US
dc.date.coverdateDiciembre 2020en_US
dc.identifier.ulpgcSíes
dc.description.sjr0,82
dc.description.jcr4,072
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IOCAG: Oceanografía Biológica y Algología Aplicada-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.orcid0000-0002-7450-0505-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.fullNameMartel Quintana,Antera De Jesús-
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