Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/74714
Título: Antitumoral potential of carbamidocyclophanes and carbamidocylindrofridin A isolated from the cyanobacterium Cylindrospermum stagnale BEA 0605B
Autores/as: Tena Pérez, Víctor
Apaza Ticona, Luis
Cabanillas, Alfredo H.
Maderuelo Corral, Santiago
Perles, Josefina
Rosero Valencia, Diego Fernando
Martel Quintana, Antera 
Ortega Domenech, Montserrat
Rumbero Sánchez, Ángel
Clasificación UNESCO: 23 Química
32 Ciencias médicas
Palabras clave: Anti-Tumour
Carbamidocyclophane
Carbamidocylindrofridin
Cyanobacterium
Cylindrospermum Stagnale, et al.
Fecha de publicación: 2020
Publicación seriada: Phytochemistry 
Resumen: Three carbamidocyclophanes, A, F and V, and carbamidocylindrofridin A were isolated from the cultured freshwater cyanobacterium Cylindrospermum stagnale, collected in the Canary Islands. The chemical structures of these compounds were elucidated through NMR, HRMS and ECD spectroscopy. The absolute configuration of carbamidocyclophane A was confirmed using X-ray-diffraction. All compounds showed apoptotic capacity against the SK-MEL-1, SK-MEL-28 and SK-MEL-31 tumour cells. Carbamidocylindrofridin A had the highest anti-tumour potential, with an IC50 of 1 ± 0.3 μM in the SK-MEL-1 cell line.
URI: http://hdl.handle.net/10553/74714
ISSN: 0031-9422
DOI: 10.1016/j.phytochem.2020.112529
Fuente: Phytochemistry [ISSN 0031-9422], v. 180, (Diciembre 2020)
Colección:Artículos
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