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http://hdl.handle.net/10553/74714
| Título: | Antitumoral potential of carbamidocyclophanes and carbamidocylindrofridin A isolated from the cyanobacterium Cylindrospermum stagnale BEA 0605B | Autores/as: | Tena Pérez, Víctor Apaza Ticona, Luis Cabanillas, Alfredo H. Maderuelo Corral, Santiago Perles, Josefina Rosero Valencia, Diego Fernando Martel Quintana, Antera Ortega Domenech, Montserrat Rumbero Sánchez, Ángel |
Clasificación UNESCO: | 23 Química 32 Ciencias médicas |
Palabras clave: | Anti-Tumour Carbamidocyclophane Carbamidocylindrofridin Cyanobacterium Cylindrospermum Stagnale, et al. |
Fecha de publicación: | 2020 | Publicación seriada: | Phytochemistry | Resumen: | Three carbamidocyclophanes, A, F and V, and carbamidocylindrofridin A were isolated from the cultured freshwater cyanobacterium Cylindrospermum stagnale, collected in the Canary Islands. The chemical structures of these compounds were elucidated through NMR, HRMS and ECD spectroscopy. The absolute configuration of carbamidocyclophane A was confirmed using X-ray-diffraction. All compounds showed apoptotic capacity against the SK-MEL-1, SK-MEL-28 and SK-MEL-31 tumour cells. Carbamidocylindrofridin A had the highest anti-tumour potential, with an IC50 of 1 ± 0.3 μM in the SK-MEL-1 cell line. | URI: | http://hdl.handle.net/10553/74714 | ISSN: | 0031-9422 | DOI: | 10.1016/j.phytochem.2020.112529 | Fuente: | Phytochemistry [ISSN 0031-9422], v. 180, (Diciembre 2020) |
| Colección: | Artículos |
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