Please use this identifier to cite or link to this item:
Title: Cord blood levels of cytokines as predictors of early neonatal sepsis
Authors: Santana, Cristhian
Guindeo, M. C.
González, G.
García-Muñoz, Fermín
Saavedra, P.
Doménech, Eduardo
UNESCO Clasification: 320108 Ginecología
320504 Hematología
Keywords: Interleukin-1 Beta
Neonatal Sepsis
Soluble Receptor Of Interleukin-2, et al
Issue Date: 2001
Journal: Acta Paediatrica, International Journal of Paediatrics 
Abstract: Aim: To investigate whether cord blood levels of C-reactive protein, interleukin-1 beta, interleukin-6, interleukin- 8, tumour necrosis factor-alpha and the soluble receptor of interleukin-2, are useful markers in the diagnosis of early neonatal sepsis. Design: Umbilical cord blood samples were obtained at birth from 261 neonates, but 5 of these newborns were excluded from the study. Group I included 10 newborns that developed early neonatal sepsis with a positive blood culture; Group II included 11 newborns with non-infectious perinatal diseases, Group III, which served as the control group, included 10 randomly selected patients, matched for gestational age, among the 235 healthy newborn babies. Results: There were no differences among the three study groups in levels of reactive protein, interleukin-1 beta, tumour necrosis factor-a and the soluble receptor of interteukin-2. Interleukin-6 was significantly elevated in Group I (360.4 +/- 157.8 pg/ml) and Group II (158.8 +/- 122.3 pg/ml), when compared with Group III (8.6 +/- 3.12 pg/ml) (p < 0.01), whereas interleukin-8 was significantly elevated in Group I (389.3 +/- 115.9 pg/ml) compared with Groups 11 (30.2 +/- 5.1 pg/ml) (p < 0.05) and III (33.9 +/- 8.6 pg/ml) (p < 0.05). A cut-off of 100.8 pg/ml for interleukin-6 obtained by the ROC (receiver operating characteristic) method gave a sensitivity of 50% and a specificity of 87%, and a cut-off of 111.7 pg/ml for interleukin-8 showed a sensitivity of 78% and a specificity of 91%.Conclusion: While cord blood levels of interleukin-6 appear to be related to pathological conditions in the perinatal period (infectious and non-infectious), interieukin-8 seems to be a good predictor of early bacterial neonatal infection.
ISSN: 0803-5253
DOI: 10.1080/080352501317061602
Source: Acta Paediatrica [ISSN 0803-5253], v. 90 (10), p. 1176-1181, (Octubre 2001)
Appears in Collections:Artículos
Show full item record


checked on Sep 25, 2022


checked on Sep 25, 2022

Page view(s)

checked on May 21, 2022

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.