Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/74345
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Santana, Cristhian | en_US |
dc.contributor.author | Guindeo, M. C. | en_US |
dc.contributor.author | González Azpeitia, Gloria | en_US |
dc.contributor.author | García-Muñoz, Fermín | en_US |
dc.contributor.author | Saavedra Santana, Pedro | en_US |
dc.contributor.author | Doménech Martínez, Eduardo | en_US |
dc.date.accessioned | 2020-09-10T11:04:48Z | - |
dc.date.available | 2020-09-10T11:04:48Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.issn | 0803-5253 | en_US |
dc.identifier.other | WoS | - |
dc.identifier.uri | http://hdl.handle.net/10553/74345 | - |
dc.description.abstract | Aim: To investigate whether cord blood levels of C-reactive protein, interleukin-1 beta, interleukin-6, interleukin- 8, tumour necrosis factor-alpha and the soluble receptor of interleukin-2, are useful markers in the diagnosis of early neonatal sepsis. Design: Umbilical cord blood samples were obtained at birth from 261 neonates, but 5 of these newborns were excluded from the study. Group I included 10 newborns that developed early neonatal sepsis with a positive blood culture; Group II included 11 newborns with non-infectious perinatal diseases, Group III, which served as the control group, included 10 randomly selected patients, matched for gestational age, among the 235 healthy newborn babies. Results: There were no differences among the three study groups in levels of reactive protein, interleukin-1 beta, tumour necrosis factor-a and the soluble receptor of interteukin-2. Interleukin-6 was significantly elevated in Group I (360.4 +/- 157.8 pg/ml) and Group II (158.8 +/- 122.3 pg/ml), when compared with Group III (8.6 +/- 3.12 pg/ml) (p < 0.01), whereas interleukin-8 was significantly elevated in Group I (389.3 +/- 115.9 pg/ml) compared with Groups 11 (30.2 +/- 5.1 pg/ml) (p < 0.05) and III (33.9 +/- 8.6 pg/ml) (p < 0.05). A cut-off of 100.8 pg/ml for interleukin-6 obtained by the ROC (receiver operating characteristic) method gave a sensitivity of 50% and a specificity of 87%, and a cut-off of 111.7 pg/ml for interleukin-8 showed a sensitivity of 78% and a specificity of 91%.Conclusion: While cord blood levels of interleukin-6 appear to be related to pathological conditions in the perinatal period (infectious and non-infectious), interieukin-8 seems to be a good predictor of early bacterial neonatal infection. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Acta Paediatrica, International Journal of Paediatrics | en_US |
dc.source | Acta Paediatrica [ISSN 0803-5253], v. 90 (10), p. 1176-1181, (Octubre 2001) | en_US |
dc.subject | 320108 Ginecología | en_US |
dc.subject | 320504 Hematología | en_US |
dc.subject.other | Interleukin-1 Beta | en_US |
dc.subject.other | Interleukin-6 | en_US |
dc.subject.other | Interleukin-8 | en_US |
dc.subject.other | Neonatal Sepsis | en_US |
dc.subject.other | Soluble Receptor Of Interleukin-2 | en_US |
dc.subject.other | Tumour Necrosis Factor-Alpha | en_US |
dc.title | Cord blood levels of cytokines as predictors of early neonatal sepsis | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1080/080352501317061602 | en_US |
dc.identifier.scopus | 0034787413 | - |
dc.identifier.isi | 000171709200020 | - |
dc.contributor.authorscopusid | 57207522482 | - |
dc.contributor.authorscopusid | 6506782744 | - |
dc.contributor.authorscopusid | 7202571279 | - |
dc.contributor.authorscopusid | 57214558171 | - |
dc.contributor.authorscopusid | 56677724200 | - |
dc.contributor.authorscopusid | 7006650754 | - |
dc.description.lastpage | 1181 | en_US |
dc.identifier.issue | 10 | - |
dc.description.firstpage | 1176 | en_US |
dc.relation.volume | 90 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
local.message.claim | 2023-06-16T20:23:58.439+0100|||rp01021|||submit_approve|||dc_contributor_author|||DIRECTOR DE LA TESIS GONZALEZ AZPEITIA GLORIA | - |
dc.contributor.daisngid | 6920645 | - |
dc.contributor.daisngid | 3849639 | - |
dc.contributor.daisngid | 10250946 | - |
dc.contributor.daisngid | 3613414 | - |
dc.contributor.daisngid | 247998 | - |
dc.contributor.daisngid | 1027193 | - |
dc.description.numberofpages | 6 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Santana, C | - |
dc.contributor.wosstandard | WOS:Guindeo, MC | - |
dc.contributor.wosstandard | WOS:Gonzalez, G | - |
dc.contributor.wosstandard | WOS:Garcia-Munoz, F | - |
dc.contributor.wosstandard | WOS:Saavedra, P | - |
dc.contributor.wosstandard | WOS:Domenech, E | - |
dc.date.coverdate | Enero 2001 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 1,582 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | restricted | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUIBS: Nutrición | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR Estadística | - |
crisitem.author.dept | Departamento de Matemáticas | - |
crisitem.author.orcid | 0009-0004-2207-9095 | - |
crisitem.author.orcid | 0000-0003-1681-7165 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | Departamento de Matemáticas | - |
crisitem.author.fullName | González Azpeitia, Gloria | - |
crisitem.author.fullName | Saavedra Santana, Pedro | - |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
76
checked on Sep 29, 2024
WEB OF SCIENCETM
Citations
68
checked on Sep 29, 2024
Page view(s)
100
checked on Feb 17, 2024
Download(s)
22
checked on Feb 17, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.