Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74345
DC FieldValueLanguage
dc.contributor.authorSantana, Cristhianen_US
dc.contributor.authorGuindeo, M. C.en_US
dc.contributor.authorGonzález, G.en_US
dc.contributor.authorGarcía-Muñoz, Fermínen_US
dc.contributor.authorSaavedra, P.en_US
dc.contributor.authorDoménech, Eduardoen_US
dc.date.accessioned2020-09-10T11:04:48Z-
dc.date.available2020-09-10T11:04:48Z-
dc.date.issued2001en_US
dc.identifier.issn0803-5253en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/74345-
dc.description.abstractAim: To investigate whether cord blood levels of C-reactive protein, interleukin-1 beta, interleukin-6, interleukin- 8, tumour necrosis factor-alpha and the soluble receptor of interleukin-2, are useful markers in the diagnosis of early neonatal sepsis. Design: Umbilical cord blood samples were obtained at birth from 261 neonates, but 5 of these newborns were excluded from the study. Group I included 10 newborns that developed early neonatal sepsis with a positive blood culture; Group II included 11 newborns with non-infectious perinatal diseases, Group III, which served as the control group, included 10 randomly selected patients, matched for gestational age, among the 235 healthy newborn babies. Results: There were no differences among the three study groups in levels of reactive protein, interleukin-1 beta, tumour necrosis factor-a and the soluble receptor of interteukin-2. Interleukin-6 was significantly elevated in Group I (360.4 +/- 157.8 pg/ml) and Group II (158.8 +/- 122.3 pg/ml), when compared with Group III (8.6 +/- 3.12 pg/ml) (p < 0.01), whereas interleukin-8 was significantly elevated in Group I (389.3 +/- 115.9 pg/ml) compared with Groups 11 (30.2 +/- 5.1 pg/ml) (p < 0.05) and III (33.9 +/- 8.6 pg/ml) (p < 0.05). A cut-off of 100.8 pg/ml for interleukin-6 obtained by the ROC (receiver operating characteristic) method gave a sensitivity of 50% and a specificity of 87%, and a cut-off of 111.7 pg/ml for interleukin-8 showed a sensitivity of 78% and a specificity of 91%.Conclusion: While cord blood levels of interleukin-6 appear to be related to pathological conditions in the perinatal period (infectious and non-infectious), interieukin-8 seems to be a good predictor of early bacterial neonatal infection.en_US
dc.languageengen_US
dc.relation.ispartofActa Paediatrica, International Journal of Paediatricsen_US
dc.sourceActa Paediatrica [ISSN 0803-5253], v. 90 (10), p. 1176-1181, (Octubre 2001)en_US
dc.subject320108 Ginecologíaen_US
dc.subject320504 Hematologíaen_US
dc.subject.otherInterleukin-1 Betaen_US
dc.subject.otherInterleukin-6en_US
dc.subject.otherInterleukin-8en_US
dc.subject.otherNeonatal Sepsisen_US
dc.subject.otherSoluble Receptor Of Interleukin-2en_US
dc.subject.otherTumour Necrosis Factor-Alphaen_US
dc.titleCord blood levels of cytokines as predictors of early neonatal sepsisen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/080352501317061602en_US
dc.identifier.scopus0034787413-
dc.identifier.isi000171709200020-
dc.contributor.authorscopusid57207522482-
dc.contributor.authorscopusid6506782744-
dc.contributor.authorscopusid7202571279-
dc.contributor.authorscopusid57214558171-
dc.contributor.authorscopusid56677724200-
dc.contributor.authorscopusid7006650754-
dc.description.lastpage1181en_US
dc.identifier.issue10-
dc.description.firstpage1176en_US
dc.relation.volume90en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid6920645-
dc.contributor.daisngid3849639-
dc.contributor.daisngid10250946-
dc.contributor.daisngid3613414-
dc.contributor.daisngid247998-
dc.contributor.daisngid1027193-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Santana, C-
dc.contributor.wosstandardWOS:Guindeo, MC-
dc.contributor.wosstandardWOS:Gonzalez, G-
dc.contributor.wosstandardWOS:Garcia-Munoz, F-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:Domenech, E-
dc.date.coverdateEnero 2001en_US
dc.identifier.ulpgces
dc.description.jcr1,582
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
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