Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/74345
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Santana, Cristhian | en_US |
dc.contributor.author | Guindeo, M. C. | en_US |
dc.contributor.author | González Azpeitia, Gloria | en_US |
dc.contributor.author | García-Muñoz, Fermín | en_US |
dc.contributor.author | Saavedra Santana, Pedro | en_US |
dc.contributor.author | Doménech Martínez, Eduardo | en_US |
dc.date.accessioned | 2020-09-10T11:04:48Z | - |
dc.date.available | 2020-09-10T11:04:48Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.issn | 0803-5253 | en_US |
dc.identifier.other | WoS | - |
dc.identifier.uri | http://hdl.handle.net/10553/74345 | - |
dc.description.abstract | Aim: To investigate whether cord blood levels of C-reactive protein, interleukin-1 beta, interleukin-6, interleukin- 8, tumour necrosis factor-alpha and the soluble receptor of interleukin-2, are useful markers in the diagnosis of early neonatal sepsis. Design: Umbilical cord blood samples were obtained at birth from 261 neonates, but 5 of these newborns were excluded from the study. Group I included 10 newborns that developed early neonatal sepsis with a positive blood culture; Group II included 11 newborns with non-infectious perinatal diseases, Group III, which served as the control group, included 10 randomly selected patients, matched for gestational age, among the 235 healthy newborn babies. Results: There were no differences among the three study groups in levels of reactive protein, interleukin-1 beta, tumour necrosis factor-a and the soluble receptor of interteukin-2. Interleukin-6 was significantly elevated in Group I (360.4 +/- 157.8 pg/ml) and Group II (158.8 +/- 122.3 pg/ml), when compared with Group III (8.6 +/- 3.12 pg/ml) (p < 0.01), whereas interleukin-8 was significantly elevated in Group I (389.3 +/- 115.9 pg/ml) compared with Groups 11 (30.2 +/- 5.1 pg/ml) (p < 0.05) and III (33.9 +/- 8.6 pg/ml) (p < 0.05). A cut-off of 100.8 pg/ml for interleukin-6 obtained by the ROC (receiver operating characteristic) method gave a sensitivity of 50% and a specificity of 87%, and a cut-off of 111.7 pg/ml for interleukin-8 showed a sensitivity of 78% and a specificity of 91%.Conclusion: While cord blood levels of interleukin-6 appear to be related to pathological conditions in the perinatal period (infectious and non-infectious), interieukin-8 seems to be a good predictor of early bacterial neonatal infection. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Acta Paediatrica, International Journal of Paediatrics | en_US |
dc.source | Acta Paediatrica [ISSN 0803-5253], v. 90 (10), p. 1176-1181, (Octubre 2001) | en_US |
dc.subject | 320108 Ginecología | en_US |
dc.subject | 320504 Hematología | en_US |
dc.subject.other | Interleukin-1 Beta | en_US |
dc.subject.other | Interleukin-6 | en_US |
dc.subject.other | Interleukin-8 | en_US |
dc.subject.other | Neonatal Sepsis | en_US |
dc.subject.other | Soluble Receptor Of Interleukin-2 | en_US |
dc.subject.other | Tumour Necrosis Factor-Alpha | en_US |
dc.title | Cord blood levels of cytokines as predictors of early neonatal sepsis | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1080/080352501317061602 | en_US |
dc.identifier.scopus | 0034787413 | - |
dc.identifier.isi | 000171709200020 | - |
dc.contributor.authorscopusid | 57207522482 | - |
dc.contributor.authorscopusid | 6506782744 | - |
dc.contributor.authorscopusid | 7202571279 | - |
dc.contributor.authorscopusid | 57214558171 | - |
dc.contributor.authorscopusid | 56677724200 | - |
dc.contributor.authorscopusid | 7006650754 | - |
dc.description.lastpage | 1181 | en_US |
dc.identifier.issue | 10 | - |
dc.description.firstpage | 1176 | en_US |
dc.relation.volume | 90 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
local.message.claim | 2023-06-16T20:23:58.439+0100|||rp01021|||submit_approve|||dc_contributor_author|||DIRECTOR DE LA TESIS GONZALEZ AZPEITIA GLORIA | - |
dc.contributor.daisngid | 6920645 | - |
dc.contributor.daisngid | 3849639 | - |
dc.contributor.daisngid | 10250946 | - |
dc.contributor.daisngid | 3613414 | - |
dc.contributor.daisngid | 247998 | - |
dc.contributor.daisngid | 1027193 | - |
dc.description.numberofpages | 6 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Santana, C | - |
dc.contributor.wosstandard | WOS:Guindeo, MC | - |
dc.contributor.wosstandard | WOS:Gonzalez, G | - |
dc.contributor.wosstandard | WOS:Garcia-Munoz, F | - |
dc.contributor.wosstandard | WOS:Saavedra, P | - |
dc.contributor.wosstandard | WOS:Domenech, E | - |
dc.date.coverdate | Enero 2001 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 1,582 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | restricted | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUIBS: Nutrición | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR Estadística | - |
crisitem.author.dept | Departamento de Matemáticas | - |
crisitem.author.orcid | 0009-0004-2207-9095 | - |
crisitem.author.orcid | 0000-0003-1681-7165 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | Departamento de Matemáticas | - |
crisitem.author.fullName | González Azpeitia, Gloria | - |
crisitem.author.fullName | Saavedra Santana, Pedro | - |
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