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Title: Targeting molecular interactions essential for Plasmodium sexual reproduction
Authors: Vega-Rodriguez, Joel
Pérez Barreto,Davinia 
Ruiz Reyes, Antonio 
Jacobs-Lorena, Marcelo
UNESCO Clasification: 32 Ciencias médicas
Issue Date: 2015
Journal: Cellular Microbiology 
Abstract: Malaria remains one of the most devastating infectious diseases, killing up to a million people every year. Whereas much progress has been made in understanding the life cycle of the parasite in the human host and in the mosquito vector, significant gaps of knowledge remain. Fertilization of malaria parasites, a process that takes place in the lumen of the mosquito midgut, is poorly understood and the molecular interactions (receptor-ligand) required for Plasmodium fertilization remain elusive. By use of a phage display library, we identified FG1 (Female Gamete peptide 1), a peptide that binds specifically to the surface of female Plasmodiumberghei gametes. Importantly, FG1 but not a scrambled version of the peptide, strongly reduces P.berghei oocyst formation by interfering with fertilization. In addition, FG1 also inhibits P.falciparum oocyst formation suggesting that the peptide binds to a molecule on the surface of the female gamete whose structure is conserved. Identification of the molecular interactions disrupted by the FG1 peptide may lead to the development of novel malaria transmission-blocking strategies.
ISSN: 1462-5814
DOI: 10.1111/cmi.12458
Source: Cellular Microbiology [ISSN 1462-5814], v. 17 (11), p. 1594-1604, (Noviembre 2015)
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