Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74024
DC FieldValueLanguage
dc.contributor.authorVega-Rodriguez, Joelen_US
dc.contributor.authorPérez Barreto,Daviniaen_US
dc.contributor.authorRuiz Reyes, Antonioen_US
dc.contributor.authorJacobs-Lorena, Marceloen_US
dc.date.accessioned2020-08-07T09:02:22Z-
dc.date.available2020-08-07T09:02:22Z-
dc.date.issued2015en_US
dc.identifier.issn1462-5814en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/74024-
dc.description.abstractMalaria remains one of the most devastating infectious diseases, killing up to a million people every year. Whereas much progress has been made in understanding the life cycle of the parasite in the human host and in the mosquito vector, significant gaps of knowledge remain. Fertilization of malaria parasites, a process that takes place in the lumen of the mosquito midgut, is poorly understood and the molecular interactions (receptor-ligand) required for Plasmodium fertilization remain elusive. By use of a phage display library, we identified FG1 (Female Gamete peptide 1), a peptide that binds specifically to the surface of female Plasmodiumberghei gametes. Importantly, FG1 but not a scrambled version of the peptide, strongly reduces P.berghei oocyst formation by interfering with fertilization. In addition, FG1 also inhibits P.falciparum oocyst formation suggesting that the peptide binds to a molecule on the surface of the female gamete whose structure is conserved. Identification of the molecular interactions disrupted by the FG1 peptide may lead to the development of novel malaria transmission-blocking strategies.en_US
dc.languageengen_US
dc.relation.ispartofCellular Microbiologyen_US
dc.sourceCellular Microbiology [ISSN 1462-5814], v. 17 (11), p. 1594-1604, (Noviembre 2015)en_US
dc.subject32 Ciencias médicasen_US
dc.titleTargeting molecular interactions essential for Plasmodium sexual reproductionen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/cmi.12458en_US
dc.identifier.scopus84945316633-
dc.contributor.authorscopusid26041091600-
dc.contributor.authorscopusid56236181000-
dc.contributor.authorscopusid56925389200-
dc.contributor.authorscopusid7004974477-
dc.identifier.eissn1462-5822-
dc.description.lastpage1604en_US
dc.identifier.issue11-
dc.description.firstpage1594en_US
dc.relation.volume17en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateNoviembre 2015en_US
dc.identifier.ulpgces
dc.description.sjr2,932
dc.description.jcr4,46
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR Parasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-0668-5496-
crisitem.author.parentorgDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.fullNamePérez Barreto,Davinia-
crisitem.author.fullNameRuiz Reyes, Antonio-
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