Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/73901
Title: Peripheral blood lymphocyte subsets in Fasciola hepatica infected and immunised goats
Authors: Zafra Leva,Rafael 
Perez, J. 
Buffoni, L.
Martinez-Moreno, F. J.
Acosta, I.
Mozos, E.
Martinez-Moreno, A.
UNESCO Clasification: 310907 Patología
240112 Parasitología animal
Keywords: Flow Cytometry
Goat
Fasciola Hepatica
CD4
CD8
WC1
Issue Date: 2013
Journal: Veterinary Immunology and Immunopathology 
Abstract: The proportions of CD4(+), CD8(+) and WC1(+) T lymphocytes from peripheral blood using flow cytometry were investigated in goats infected with Fasciola hepatica and previously immunised with recombinant Cathepsin-L1 (rCL1) and Glutathione-S-transferase sigma class (GST). The immunisation trial did not induce protective responses, and no significant differences were recorded between immunised and non-immunised groups. However, there was a significant decrease in the proportion of CD4(+) T lymphocytes in the infected groups both at 5 weeks post-infection (wpi), coinciding with the migratory stage of the infection, and at 12 wpi in the biliary stage of the infection. The proportional decrease in this circulating population may be related to the recruitment of CD4(+) T cells in liver and hepatic lymph nodes and also to the immunomodulatory effect of the parasite through the interaction of F. hepatica excretory-secretory products (FhESP) with this cell population. To date, this is the first report about the effect of F. hepatica infection in peripheral lymphocyte subsets in goats.
URI: http://hdl.handle.net/10553/73901
ISSN: 0165-2427
DOI: 10.1016/j.vetimm.2013.06.006
Source: Veterinary Immunology And Immunopathology [ISSN 0165-2427], v. 155 (1-2), p. 135-138, (Septiembre 2013)
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