Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/73901
DC FieldValueLanguage
dc.contributor.authorZafra Leva,Rafaelen_US
dc.contributor.authorPerez, J.en_US
dc.contributor.authorBuffoni, L.en_US
dc.contributor.authorMartinez-Moreno, F. J.en_US
dc.contributor.authorAcosta, I.en_US
dc.contributor.authorMozos, E.en_US
dc.contributor.authorMartinez-Moreno, A.en_US
dc.date.accessioned2020-07-31T11:43:01Z-
dc.date.available2020-07-31T11:43:01Z-
dc.date.issued2013en_US
dc.identifier.issn0165-2427en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/73901-
dc.description.abstractThe proportions of CD4(+), CD8(+) and WC1(+) T lymphocytes from peripheral blood using flow cytometry were investigated in goats infected with Fasciola hepatica and previously immunised with recombinant Cathepsin-L1 (rCL1) and Glutathione-S-transferase sigma class (GST). The immunisation trial did not induce protective responses, and no significant differences were recorded between immunised and non-immunised groups. However, there was a significant decrease in the proportion of CD4(+) T lymphocytes in the infected groups both at 5 weeks post-infection (wpi), coinciding with the migratory stage of the infection, and at 12 wpi in the biliary stage of the infection. The proportional decrease in this circulating population may be related to the recruitment of CD4(+) T cells in liver and hepatic lymph nodes and also to the immunomodulatory effect of the parasite through the interaction of F. hepatica excretory-secretory products (FhESP) with this cell population. To date, this is the first report about the effect of F. hepatica infection in peripheral lymphocyte subsets in goats.en_US
dc.languageengen_US
dc.relation.ispartofVeterinary Immunology and Immunopathologyen_US
dc.sourceVeterinary Immunology And Immunopathology [ISSN 0165-2427], v. 155 (1-2), p. 135-138, (Septiembre 2013)en_US
dc.subject310907 Patologíaen_US
dc.subject240112 Parasitología animalen_US
dc.subject.otherFlow Cytometryen_US
dc.subject.otherGoaten_US
dc.subject.otherFasciola Hepaticaen_US
dc.subject.otherCD4en_US
dc.subject.otherCD8en_US
dc.subject.otherWC1en_US
dc.titlePeripheral blood lymphocyte subsets in Fasciola hepatica infected and immunised goatsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.vetimm.2013.06.006en_US
dc.identifier.scopus84881022687-
dc.identifier.isi000323457700016-
dc.contributor.authorscopusid23029634000-
dc.contributor.authorscopusid55597088351-
dc.contributor.authorscopusid23567522100-
dc.contributor.authorscopusid6603383525-
dc.contributor.authorscopusid6601964243-
dc.contributor.authorscopusid7003461159-
dc.contributor.authorscopusid15725365500-
dc.identifier.eissn1873-2534-
dc.description.lastpage138en_US
dc.identifier.issue1-2-
dc.description.firstpage135en_US
dc.relation.volume155en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid770447-
dc.contributor.daisngid319037-
dc.contributor.daisngid2280645-
dc.contributor.daisngid31450330-
dc.contributor.daisngid2040005-
dc.contributor.daisngid676422-
dc.contributor.daisngid984836-
dc.description.numberofpages4en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Zafra, R-
dc.contributor.wosstandardWOS:Perez, J-
dc.contributor.wosstandardWOS:Buffoni, L-
dc.contributor.wosstandardWOS:Martinez-Moreno, FJ-
dc.contributor.wosstandardWOS:Acosta, I-
dc.contributor.wosstandardWOS:Mozos, E-
dc.contributor.wosstandardWOS:Martinez-Moreno, A-
dc.date.coverdateSeptiembre 2013en_US
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.orcid0000-0001-5726-3731-
crisitem.author.fullNameZafra Leva,Rafaael-
crisitem.author.fullNameÁlvarez Pérez, Jacqueline-
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